Cargando…
Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex
BACKGROUND: Motor information in the brain is transmitted from the dorsal premotor cortex (PMd) to the primary motor cortex (M1), where it is further processed and relayed to the spinal cord to eventually generate muscle movement. However, how information from the PMd affects M1 processing and the f...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346859/ https://www.ncbi.nlm.nih.gov/pubmed/32704437 http://dx.doi.org/10.7717/peerj.9253 |
_version_ | 1783556480238092288 |
---|---|
author | Meng, Hai-Jiang Cao, Na Zhang, Jian Pi, Yan-Ling |
author_facet | Meng, Hai-Jiang Cao, Na Zhang, Jian Pi, Yan-Ling |
author_sort | Meng, Hai-Jiang |
collection | PubMed |
description | BACKGROUND: Motor information in the brain is transmitted from the dorsal premotor cortex (PMd) to the primary motor cortex (M1), where it is further processed and relayed to the spinal cord to eventually generate muscle movement. However, how information from the PMd affects M1 processing and the final output is unclear. Here, we applied intermittent theta burst stimulation (iTBS) to the PMd to alter cortical excitability not only at the application site but also at the PMd projection site of M1. We aimed to determine how PMd iTBS–altered information changed M1 processing and the corticospinal output. METHODS: In total, 16 young, healthy participants underwent PMd iTBS with 600 pulses (iTBS600) or sham-iTBS600. Corticospinal excitability, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were measured using transcranial magnetic stimulation before and up to 60 min after stimulation. RESULTS: Corticospinal excitability in M1 was significantly greater 15 min after PMd iTBS600 than that after sham-iTBS600 (p = 0.012). Compared with that after sham-iTBS600, at 0 (p = 0.014) and 15 (p = 0.037) min after iTBS600, SICI in M1 was significantly decreased, whereas 15 min after iTBS600, ICF in M1 was significantly increased (p = 0.033). CONCLUSION: Our results suggested that projections from the PMd to M1 facilitated M1 corticospinal output and that this facilitation may be attributable in part to decreased intracortical inhibition and increased intracortical facilitation in M1. Such a facilitatory network may inform future understanding of the allocation of resources to achieve optimal motion output. |
format | Online Article Text |
id | pubmed-7346859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73468592020-07-22 Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex Meng, Hai-Jiang Cao, Na Zhang, Jian Pi, Yan-Ling PeerJ Neuroscience BACKGROUND: Motor information in the brain is transmitted from the dorsal premotor cortex (PMd) to the primary motor cortex (M1), where it is further processed and relayed to the spinal cord to eventually generate muscle movement. However, how information from the PMd affects M1 processing and the final output is unclear. Here, we applied intermittent theta burst stimulation (iTBS) to the PMd to alter cortical excitability not only at the application site but also at the PMd projection site of M1. We aimed to determine how PMd iTBS–altered information changed M1 processing and the corticospinal output. METHODS: In total, 16 young, healthy participants underwent PMd iTBS with 600 pulses (iTBS600) or sham-iTBS600. Corticospinal excitability, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) were measured using transcranial magnetic stimulation before and up to 60 min after stimulation. RESULTS: Corticospinal excitability in M1 was significantly greater 15 min after PMd iTBS600 than that after sham-iTBS600 (p = 0.012). Compared with that after sham-iTBS600, at 0 (p = 0.014) and 15 (p = 0.037) min after iTBS600, SICI in M1 was significantly decreased, whereas 15 min after iTBS600, ICF in M1 was significantly increased (p = 0.033). CONCLUSION: Our results suggested that projections from the PMd to M1 facilitated M1 corticospinal output and that this facilitation may be attributable in part to decreased intracortical inhibition and increased intracortical facilitation in M1. Such a facilitatory network may inform future understanding of the allocation of resources to achieve optimal motion output. PeerJ Inc. 2020-07-06 /pmc/articles/PMC7346859/ /pubmed/32704437 http://dx.doi.org/10.7717/peerj.9253 Text en ©2020 Meng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Neuroscience Meng, Hai-Jiang Cao, Na Zhang, Jian Pi, Yan-Ling Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title | Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title_full | Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title_fullStr | Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title_full_unstemmed | Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title_short | Intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
title_sort | intermittent theta burst stimulation facilitates functional connectivity from the dorsal premotor cortex to primary motor cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346859/ https://www.ncbi.nlm.nih.gov/pubmed/32704437 http://dx.doi.org/10.7717/peerj.9253 |
work_keys_str_mv | AT menghaijiang intermittentthetaburststimulationfacilitatesfunctionalconnectivityfromthedorsalpremotorcortextoprimarymotorcortex AT caona intermittentthetaburststimulationfacilitatesfunctionalconnectivityfromthedorsalpremotorcortextoprimarymotorcortex AT zhangjian intermittentthetaburststimulationfacilitatesfunctionalconnectivityfromthedorsalpremotorcortextoprimarymotorcortex AT piyanling intermittentthetaburststimulationfacilitatesfunctionalconnectivityfromthedorsalpremotorcortextoprimarymotorcortex |