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Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader

Patient: Male, 65-year-old Final Diagnosis: Giant inflammatory polyps in diverticular disease Symptoms: Abdominal pain • constipation Medication:— Clinical Procedure: — Specialty: Pathology OBJECTIVE: Unusual clinical course BACKGROUND: Inflammatory pseudopolyps (IPPs) are a common manifestation in...

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Autores principales: Katerji, Roula, Huber, Aaron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347030/
https://www.ncbi.nlm.nih.gov/pubmed/32595204
http://dx.doi.org/10.12659/AJCR.923242
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author Katerji, Roula
Huber, Aaron R.
author_facet Katerji, Roula
Huber, Aaron R.
author_sort Katerji, Roula
collection PubMed
description Patient: Male, 65-year-old Final Diagnosis: Giant inflammatory polyps in diverticular disease Symptoms: Abdominal pain • constipation Medication:— Clinical Procedure: — Specialty: Pathology OBJECTIVE: Unusual clinical course BACKGROUND: Inflammatory pseudopolyps (IPPs) are a common manifestation in inflammatory bowel disease (IBD) with more cases reported with ulcerative colitis than Crohn’s disease. IPPs can grow to form large polyps which are called giant inflammatory polyps (GIPs). These polyps may cause an obstruction and form a mass-like lesion and surgical resection may be warranted. CASE REPORT: A 65-year-old male without a previous history of IBD presented with abdominal discomfort, poor appetite, constipation, weight loss, and hematochezia. Due to the high suspicion of malignancy, a computed tomography (CT) scan was performed and showed a fixed lesion in the mid sigmoid colon highly concerning for a primary colon carcinoma, with scattered diverticula, and associated with elevated carcinoembryonic antigen (CEA). Colonoscopy was done but the scope could not be passed due to obstruction. Sigmoidectomy was performed which showed a huge noninvasive lesion, which looked like pseudopolypoid serpiginous mass as giant inflammatory polyp, with scattered diverticula. On microscopic examination, pathology showed a villous polyp with numerous inflammatory cells, without any dysplasia or carcinoma. CONCLUSIONS: GIPs are rarely reported without a history of IBD. Diagnosis of GIPs can be very challenging, and surgery is sometimes indicated for definitive diagnosis.
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spelling pubmed-73470302020-07-14 Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader Katerji, Roula Huber, Aaron R. Am J Case Rep Articles Patient: Male, 65-year-old Final Diagnosis: Giant inflammatory polyps in diverticular disease Symptoms: Abdominal pain • constipation Medication:— Clinical Procedure: — Specialty: Pathology OBJECTIVE: Unusual clinical course BACKGROUND: Inflammatory pseudopolyps (IPPs) are a common manifestation in inflammatory bowel disease (IBD) with more cases reported with ulcerative colitis than Crohn’s disease. IPPs can grow to form large polyps which are called giant inflammatory polyps (GIPs). These polyps may cause an obstruction and form a mass-like lesion and surgical resection may be warranted. CASE REPORT: A 65-year-old male without a previous history of IBD presented with abdominal discomfort, poor appetite, constipation, weight loss, and hematochezia. Due to the high suspicion of malignancy, a computed tomography (CT) scan was performed and showed a fixed lesion in the mid sigmoid colon highly concerning for a primary colon carcinoma, with scattered diverticula, and associated with elevated carcinoembryonic antigen (CEA). Colonoscopy was done but the scope could not be passed due to obstruction. Sigmoidectomy was performed which showed a huge noninvasive lesion, which looked like pseudopolypoid serpiginous mass as giant inflammatory polyp, with scattered diverticula. On microscopic examination, pathology showed a villous polyp with numerous inflammatory cells, without any dysplasia or carcinoma. CONCLUSIONS: GIPs are rarely reported without a history of IBD. Diagnosis of GIPs can be very challenging, and surgery is sometimes indicated for definitive diagnosis. International Scientific Literature, Inc. 2020-06-29 /pmc/articles/PMC7347030/ /pubmed/32595204 http://dx.doi.org/10.12659/AJCR.923242 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Katerji, Roula
Huber, Aaron R.
Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title_full Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title_fullStr Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title_full_unstemmed Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title_short Giant Inflammatory Polyps in Diverticular Disease Mimicking a Colonic Mass: A Potential Malignant Masquerader
title_sort giant inflammatory polyps in diverticular disease mimicking a colonic mass: a potential malignant masquerader
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347030/
https://www.ncbi.nlm.nih.gov/pubmed/32595204
http://dx.doi.org/10.12659/AJCR.923242
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