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Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort
OBJECTIVE: To assess the predictive role of ferritin and C-reactive protein (CRP) on occurrence of macrophage activation syndrome (MAS) and mortality in patients with adult onset Still’s disease (AOSD), a rare and severe disease, included in the multicentre Gruppo Italiano di Ricerca in Reumatologia...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347102/ https://www.ncbi.nlm.nih.gov/pubmed/32645077 http://dx.doi.org/10.1371/journal.pone.0235326 |
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author | Di Benedetto, Paola Cipriani, Paola Iacono, Daniela Pantano, Ilenia Caso, Francesco Emmi, Giacomo Grembiale, Rosa Daniela Cantatore, Francesco Paolo Atzeni, Fabiola Perosa, Federico Scarpa, Raffaele Guggino, Giuliana Ciccia, Francesco Giacomelli, Roberto Ruscitti, Piero |
author_facet | Di Benedetto, Paola Cipriani, Paola Iacono, Daniela Pantano, Ilenia Caso, Francesco Emmi, Giacomo Grembiale, Rosa Daniela Cantatore, Francesco Paolo Atzeni, Fabiola Perosa, Federico Scarpa, Raffaele Guggino, Giuliana Ciccia, Francesco Giacomelli, Roberto Ruscitti, Piero |
author_sort | Di Benedetto, Paola |
collection | PubMed |
description | OBJECTIVE: To assess the predictive role of ferritin and C-reactive protein (CRP) on occurrence of macrophage activation syndrome (MAS) and mortality in patients with adult onset Still’s disease (AOSD), a rare and severe disease, included in the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort. METHODS: The predictive role, at the time of diagnosis, of serum levels of ferritin and CRP on occurrence of MAS and mortality, was evaluated by logistic regression analyses and receiver-operating characteristic (ROC) curves were built to identify patients at high risk of MAS and mortality, respectively. RESULTS: In assessed 147 patients with AOSD, levels of ferritin were predictive of MAS (OR: 1.971; P: 0.002; CI 95%: 1.280–3.035). The ROC curve showed that the best cut-off for ferritin was 1225 ng/ml in predicting MAS (sensitivity 88%; specificity 57%). Levels of CRP were predictive of mortality in these patients (OR: 2.155; P: 0.007; CI 95%: 1.228–3.783). The ROC curve showed that the best cut-off for CRP was 68.7 mg/L in predicting mortality (sensitivity 80%; specificity of 65%). CONCLUSIONS: We reported the predictive role of ferritin and CRP on MAS and mortality, respectively, in a large cohort of patients with AOSD, identifying subsets at higher risk of poor prognosis. Considering that the analysis of CRP and ferritin is widely available, these results could be readily transferable into clinical practice, thus improving the management of patients with AOSD. |
format | Online Article Text |
id | pubmed-7347102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73471022020-07-17 Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort Di Benedetto, Paola Cipriani, Paola Iacono, Daniela Pantano, Ilenia Caso, Francesco Emmi, Giacomo Grembiale, Rosa Daniela Cantatore, Francesco Paolo Atzeni, Fabiola Perosa, Federico Scarpa, Raffaele Guggino, Giuliana Ciccia, Francesco Giacomelli, Roberto Ruscitti, Piero PLoS One Research Article OBJECTIVE: To assess the predictive role of ferritin and C-reactive protein (CRP) on occurrence of macrophage activation syndrome (MAS) and mortality in patients with adult onset Still’s disease (AOSD), a rare and severe disease, included in the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort. METHODS: The predictive role, at the time of diagnosis, of serum levels of ferritin and CRP on occurrence of MAS and mortality, was evaluated by logistic regression analyses and receiver-operating characteristic (ROC) curves were built to identify patients at high risk of MAS and mortality, respectively. RESULTS: In assessed 147 patients with AOSD, levels of ferritin were predictive of MAS (OR: 1.971; P: 0.002; CI 95%: 1.280–3.035). The ROC curve showed that the best cut-off for ferritin was 1225 ng/ml in predicting MAS (sensitivity 88%; specificity 57%). Levels of CRP were predictive of mortality in these patients (OR: 2.155; P: 0.007; CI 95%: 1.228–3.783). The ROC curve showed that the best cut-off for CRP was 68.7 mg/L in predicting mortality (sensitivity 80%; specificity of 65%). CONCLUSIONS: We reported the predictive role of ferritin and CRP on MAS and mortality, respectively, in a large cohort of patients with AOSD, identifying subsets at higher risk of poor prognosis. Considering that the analysis of CRP and ferritin is widely available, these results could be readily transferable into clinical practice, thus improving the management of patients with AOSD. Public Library of Science 2020-07-09 /pmc/articles/PMC7347102/ /pubmed/32645077 http://dx.doi.org/10.1371/journal.pone.0235326 Text en © 2020 Di Benedetto et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Di Benedetto, Paola Cipriani, Paola Iacono, Daniela Pantano, Ilenia Caso, Francesco Emmi, Giacomo Grembiale, Rosa Daniela Cantatore, Francesco Paolo Atzeni, Fabiola Perosa, Federico Scarpa, Raffaele Guggino, Giuliana Ciccia, Francesco Giacomelli, Roberto Ruscitti, Piero Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title | Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title_full | Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title_fullStr | Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title_full_unstemmed | Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title_short | Ferritin and C-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset Still’s disease. Analysis of the multicentre Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale (GIRRCS) cohort |
title_sort | ferritin and c-reactive protein are predictive biomarkers of mortality and macrophage activation syndrome in adult onset still’s disease. analysis of the multicentre gruppo italiano di ricerca in reumatologia clinica e sperimentale (girrcs) cohort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347102/ https://www.ncbi.nlm.nih.gov/pubmed/32645077 http://dx.doi.org/10.1371/journal.pone.0235326 |
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