Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production

Granulomatosis with polyangiitis (GPA) is an autoimmune disease affecting mainly small blood vessels. B-cells are important in the GPA pathogenesis as precursors of autoantibody-producing cells but likely also contribute (auto)antibody-independently. This has been underlined by the effectiveness of...

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Detalles Bibliográficos
Autores principales: von Borstel, Anouk, Abdulahad, Wayel H., Dekkema, Gerjan, Rutgers, Abraham, Stegeman, Coen A., Veldman, Johanna, Heeringa, Peter, Sanders, Jan Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347169/
https://www.ncbi.nlm.nih.gov/pubmed/32645052
http://dx.doi.org/10.1371/journal.pone.0235743

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