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All three mammalian MutL complexes are required for repeat expansion in a mouse cell model of the Fragile X-related disorders
Expansion of a CGG-repeat tract in the 5’ untranslated region of the FMR1 gene causes the fragile X-related disorders (FXDs; aka the FMR1 disorders). The expansion mechanism is likely shared by the 35+ other diseases resulting from expansion of a disease-specific microsatellite, but many steps in th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347238/ https://www.ncbi.nlm.nih.gov/pubmed/32589669 http://dx.doi.org/10.1371/journal.pgen.1008902 |