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Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host imm...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347348/ https://www.ncbi.nlm.nih.gov/pubmed/32711241 http://dx.doi.org/10.1016/j.critrevonc.2020.103059 |
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author | Indini, Alice Rijavec, Erika Ghidini, Michele Bareggi, Claudia Cattaneo, Monica Galassi, Barbara Gambini, Donatella Grossi, Francesco |
author_facet | Indini, Alice Rijavec, Erika Ghidini, Michele Bareggi, Claudia Cattaneo, Monica Galassi, Barbara Gambini, Donatella Grossi, Francesco |
author_sort | Indini, Alice |
collection | PubMed |
description | The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host immune response is the main driver of tissue damage. We performed a thorough review of data on CoV pathogenesis and morbidity rate in cancer patients, through the analysis of the previous CoV pandemics. Considering the interaction between CoV and the host immune system, cancer patients receiving immunotherapy might be more at risk for an aberrant immune response in case of infection, and might therefore deserve additional precautions. The limited available data do not allow us to provide practical indications for the management of cancer patients in this critical situation. Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision. |
format | Online Article Text |
id | pubmed-7347348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73473482020-07-10 Coronavirus infection and immune system: An insight of COVID-19 in cancer patients Indini, Alice Rijavec, Erika Ghidini, Michele Bareggi, Claudia Cattaneo, Monica Galassi, Barbara Gambini, Donatella Grossi, Francesco Crit Rev Oncol Hematol Article The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host immune response is the main driver of tissue damage. We performed a thorough review of data on CoV pathogenesis and morbidity rate in cancer patients, through the analysis of the previous CoV pandemics. Considering the interaction between CoV and the host immune system, cancer patients receiving immunotherapy might be more at risk for an aberrant immune response in case of infection, and might therefore deserve additional precautions. The limited available data do not allow us to provide practical indications for the management of cancer patients in this critical situation. Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision. Elsevier B.V. 2020-09 2020-07-09 /pmc/articles/PMC7347348/ /pubmed/32711241 http://dx.doi.org/10.1016/j.critrevonc.2020.103059 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Indini, Alice Rijavec, Erika Ghidini, Michele Bareggi, Claudia Cattaneo, Monica Galassi, Barbara Gambini, Donatella Grossi, Francesco Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title | Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title_full | Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title_fullStr | Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title_full_unstemmed | Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title_short | Coronavirus infection and immune system: An insight of COVID-19 in cancer patients |
title_sort | coronavirus infection and immune system: an insight of covid-19 in cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347348/ https://www.ncbi.nlm.nih.gov/pubmed/32711241 http://dx.doi.org/10.1016/j.critrevonc.2020.103059 |
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