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Coronavirus infection and immune system: An insight of COVID-19 in cancer patients

The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host imm...

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Autores principales: Indini, Alice, Rijavec, Erika, Ghidini, Michele, Bareggi, Claudia, Cattaneo, Monica, Galassi, Barbara, Gambini, Donatella, Grossi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347348/
https://www.ncbi.nlm.nih.gov/pubmed/32711241
http://dx.doi.org/10.1016/j.critrevonc.2020.103059
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author Indini, Alice
Rijavec, Erika
Ghidini, Michele
Bareggi, Claudia
Cattaneo, Monica
Galassi, Barbara
Gambini, Donatella
Grossi, Francesco
author_facet Indini, Alice
Rijavec, Erika
Ghidini, Michele
Bareggi, Claudia
Cattaneo, Monica
Galassi, Barbara
Gambini, Donatella
Grossi, Francesco
author_sort Indini, Alice
collection PubMed
description The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host immune response is the main driver of tissue damage. We performed a thorough review of data on CoV pathogenesis and morbidity rate in cancer patients, through the analysis of the previous CoV pandemics. Considering the interaction between CoV and the host immune system, cancer patients receiving immunotherapy might be more at risk for an aberrant immune response in case of infection, and might therefore deserve additional precautions. The limited available data do not allow us to provide practical indications for the management of cancer patients in this critical situation. Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision.
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spelling pubmed-73473482020-07-10 Coronavirus infection and immune system: An insight of COVID-19 in cancer patients Indini, Alice Rijavec, Erika Ghidini, Michele Bareggi, Claudia Cattaneo, Monica Galassi, Barbara Gambini, Donatella Grossi, Francesco Crit Rev Oncol Hematol Article The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host immune response is the main driver of tissue damage. We performed a thorough review of data on CoV pathogenesis and morbidity rate in cancer patients, through the analysis of the previous CoV pandemics. Considering the interaction between CoV and the host immune system, cancer patients receiving immunotherapy might be more at risk for an aberrant immune response in case of infection, and might therefore deserve additional precautions. The limited available data do not allow us to provide practical indications for the management of cancer patients in this critical situation. Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision. Elsevier B.V. 2020-09 2020-07-09 /pmc/articles/PMC7347348/ /pubmed/32711241 http://dx.doi.org/10.1016/j.critrevonc.2020.103059 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Indini, Alice
Rijavec, Erika
Ghidini, Michele
Bareggi, Claudia
Cattaneo, Monica
Galassi, Barbara
Gambini, Donatella
Grossi, Francesco
Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title_full Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title_fullStr Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title_full_unstemmed Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title_short Coronavirus infection and immune system: An insight of COVID-19 in cancer patients
title_sort coronavirus infection and immune system: an insight of covid-19 in cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347348/
https://www.ncbi.nlm.nih.gov/pubmed/32711241
http://dx.doi.org/10.1016/j.critrevonc.2020.103059
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