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The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy

The outbreak of CoronaVirus Disease19 (COVID19) in December 2019 posed a serious threat to public safety, and its rapid spread caused a global health emergency. Clinical data show that in addition to respiratory system damage, some male patients with COVID-19 are also accompanied by abnormal renal f...

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Autor principal: Sun, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347466/
https://www.ncbi.nlm.nih.gov/pubmed/32679425
http://dx.doi.org/10.1016/j.mehy.2020.110083
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author Sun, Jun
author_facet Sun, Jun
author_sort Sun, Jun
collection PubMed
description The outbreak of CoronaVirus Disease19 (COVID19) in December 2019 posed a serious threat to public safety, and its rapid spread caused a global health emergency. Clinical data show that in addition to respiratory system damage, some male patients with COVID-19 are also accompanied by abnormal renal function and even renal damage. As the main receptor of syndrome coronavirus 2 (SARS-CoV-2), angiotensin converting enzyme 2 (ACE2) is also found to be highly expressed not only in respiratory mucosa and alveolar epithelial cells, but also in renal tubule cells, testicular Leydig cells and seminiferous tubule cells. This suggests that SARS-CoV-2 has the possibility of infecting the male reproductive system, and the recent detection of SARS-CoV-2 in the patient's semen further confirms this theory. In previous studies, it has been found that ACE2 has the ability to regulate autophagy. Not only that, recent studies have also found that SARS-CoV-2 infection can also lead to a reduction in autophagy. All of these associate SARS-CoV-2 with autophagy. Furthermore, autophagy has been shown to have an effect on male reproduction in many studies. Based on these, we propose the hypothesis that SARS-CoV-2 affects male reproductive function by regulating autophagy. This hypothesis may provide a new idea for future treatment of COVID-19 male patients with reproductive function injury, and it can also prompt medical staff and patients to consciously check their reproductive function.
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spelling pubmed-73474662020-07-10 The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy Sun, Jun Med Hypotheses Article The outbreak of CoronaVirus Disease19 (COVID19) in December 2019 posed a serious threat to public safety, and its rapid spread caused a global health emergency. Clinical data show that in addition to respiratory system damage, some male patients with COVID-19 are also accompanied by abnormal renal function and even renal damage. As the main receptor of syndrome coronavirus 2 (SARS-CoV-2), angiotensin converting enzyme 2 (ACE2) is also found to be highly expressed not only in respiratory mucosa and alveolar epithelial cells, but also in renal tubule cells, testicular Leydig cells and seminiferous tubule cells. This suggests that SARS-CoV-2 has the possibility of infecting the male reproductive system, and the recent detection of SARS-CoV-2 in the patient's semen further confirms this theory. In previous studies, it has been found that ACE2 has the ability to regulate autophagy. Not only that, recent studies have also found that SARS-CoV-2 infection can also lead to a reduction in autophagy. All of these associate SARS-CoV-2 with autophagy. Furthermore, autophagy has been shown to have an effect on male reproduction in many studies. Based on these, we propose the hypothesis that SARS-CoV-2 affects male reproductive function by regulating autophagy. This hypothesis may provide a new idea for future treatment of COVID-19 male patients with reproductive function injury, and it can also prompt medical staff and patients to consciously check their reproductive function. Elsevier Ltd. 2020-10 2020-07-10 /pmc/articles/PMC7347466/ /pubmed/32679425 http://dx.doi.org/10.1016/j.mehy.2020.110083 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sun, Jun
The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title_full The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title_fullStr The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title_full_unstemmed The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title_short The hypothesis that SARS-CoV-2 affects male reproductive ability by regulating autophagy
title_sort hypothesis that sars-cov-2 affects male reproductive ability by regulating autophagy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347466/
https://www.ncbi.nlm.nih.gov/pubmed/32679425
http://dx.doi.org/10.1016/j.mehy.2020.110083
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