Update on DNA-Double Strand Break Repair Defects in Combined Primary Immunodeficiency

PURPOSE OF REVIEW: The most serious DNA damage, DNA double strand breaks (DNA-dsb), leads to mutagenesis, carcinogenesis or apoptosis if left unrepaired. Non-homologous end joining (NHEJ) is the principle repair pathway employed by mammalian cells to repair DNA-dsb. Several proteins are involved in...

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Detalles Bibliográficos
Autores principales: Slatter, Mary A., Gennery, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Immune Deficiency and Dysregulation (C Kuo, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347510/
https://www.ncbi.nlm.nih.gov/pubmed/32648006
http://dx.doi.org/10.1007/s11882-020-00955-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347510/
https://www.ncbi.nlm.nih.gov/pubmed/32648006
http://dx.doi.org/10.1007/s11882-020-00955-z

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