Cargando…
Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstl...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347579/ https://www.ncbi.nlm.nih.gov/pubmed/32647188 http://dx.doi.org/10.1038/s41598-020-68188-8 |
_version_ | 1783556616325431296 |
---|---|
author | He, Ting Li, Xiao Wang, Xiaoping Xu, Xiao Yan, Xin Li, Xiang Sun, Siqi Dong, Ying Ren, Xueyang Liu, Xiaoyun Wang, Yu Sui, Hong Xia, Qing She, Gaimei |
author_facet | He, Ting Li, Xiao Wang, Xiaoping Xu, Xiao Yan, Xin Li, Xiang Sun, Siqi Dong, Ying Ren, Xueyang Liu, Xiaoyun Wang, Yu Sui, Hong Xia, Qing She, Gaimei |
author_sort | He, Ting |
collection | PubMed |
description | Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstly reported as a new natural product, which has been used as a synthetic flavoring substance with no safety concern. The thyme oils showed the anti-oxidant activity using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) and conferred protection against oxidative stress in zebrafish. In addition, a class of carvacrol analogues was found to develop as potential natural antioxidant products of thyme oils from Loess Plateau by the correlation analysis. YL-thyme oil performed the best antioxidant activity in this research, which could be recommended as preferred sources of thyme oils. Furthermore, YL-thyme oil exhibited a potent antioxidant capacity by reactive oxygen species (ROS) scavenging, enhancing the endogenous antioxidant system, inhibiting lipid peroxidation and activation of Keap1/Nrf2 pathway in zebrafish. |
format | Online Article Text |
id | pubmed-7347579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73475792020-07-10 Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish He, Ting Li, Xiao Wang, Xiaoping Xu, Xiao Yan, Xin Li, Xiang Sun, Siqi Dong, Ying Ren, Xueyang Liu, Xiaoyun Wang, Yu Sui, Hong Xia, Qing She, Gaimei Sci Rep Article Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstly reported as a new natural product, which has been used as a synthetic flavoring substance with no safety concern. The thyme oils showed the anti-oxidant activity using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) and conferred protection against oxidative stress in zebrafish. In addition, a class of carvacrol analogues was found to develop as potential natural antioxidant products of thyme oils from Loess Plateau by the correlation analysis. YL-thyme oil performed the best antioxidant activity in this research, which could be recommended as preferred sources of thyme oils. Furthermore, YL-thyme oil exhibited a potent antioxidant capacity by reactive oxygen species (ROS) scavenging, enhancing the endogenous antioxidant system, inhibiting lipid peroxidation and activation of Keap1/Nrf2 pathway in zebrafish. Nature Publishing Group UK 2020-07-09 /pmc/articles/PMC7347579/ /pubmed/32647188 http://dx.doi.org/10.1038/s41598-020-68188-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleΓÇÖs Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleΓÇÖs Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article He, Ting Li, Xiao Wang, Xiaoping Xu, Xiao Yan, Xin Li, Xiang Sun, Siqi Dong, Ying Ren, Xueyang Liu, Xiaoyun Wang, Yu Sui, Hong Xia, Qing She, Gaimei Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title | Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title_full | Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title_fullStr | Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title_full_unstemmed | Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title_short | Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish |
title_sort | chemical composition and anti-oxidant potential on essential oils of thymus quinquecostatus celak. from loess plateau in china, regulating nrf2/keap1 signaling pathway in zebrafish |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347579/ https://www.ncbi.nlm.nih.gov/pubmed/32647188 http://dx.doi.org/10.1038/s41598-020-68188-8 |
work_keys_str_mv | AT heting chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT lixiao chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT wangxiaoping chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT xuxiao chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT yanxin chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT lixiang chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT sunsiqi chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT dongying chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT renxueyang chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT liuxiaoyun chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT wangyu chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT suihong chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT xiaqing chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish AT shegaimei chemicalcompositionandantioxidantpotentialonessentialoilsofthymusquinquecostatuscelakfromloessplateauinchinaregulatingnrf2keap1signalingpathwayinzebrafish |