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Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish

Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstl...

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Autores principales: He, Ting, Li, Xiao, Wang, Xiaoping, Xu, Xiao, Yan, Xin, Li, Xiang, Sun, Siqi, Dong, Ying, Ren, Xueyang, Liu, Xiaoyun, Wang, Yu, Sui, Hong, Xia, Qing, She, Gaimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347579/
https://www.ncbi.nlm.nih.gov/pubmed/32647188
http://dx.doi.org/10.1038/s41598-020-68188-8
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author He, Ting
Li, Xiao
Wang, Xiaoping
Xu, Xiao
Yan, Xin
Li, Xiang
Sun, Siqi
Dong, Ying
Ren, Xueyang
Liu, Xiaoyun
Wang, Yu
Sui, Hong
Xia, Qing
She, Gaimei
author_facet He, Ting
Li, Xiao
Wang, Xiaoping
Xu, Xiao
Yan, Xin
Li, Xiang
Sun, Siqi
Dong, Ying
Ren, Xueyang
Liu, Xiaoyun
Wang, Yu
Sui, Hong
Xia, Qing
She, Gaimei
author_sort He, Ting
collection PubMed
description Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstly reported as a new natural product, which has been used as a synthetic flavoring substance with no safety concern. The thyme oils showed the anti-oxidant activity using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) and conferred protection against oxidative stress in zebrafish. In addition, a class of carvacrol analogues was found to develop as potential natural antioxidant products of thyme oils from Loess Plateau by the correlation analysis. YL-thyme oil performed the best antioxidant activity in this research, which could be recommended as preferred sources of thyme oils. Furthermore, YL-thyme oil exhibited a potent antioxidant capacity by reactive oxygen species (ROS) scavenging, enhancing the endogenous antioxidant system, inhibiting lipid peroxidation and activation of Keap1/Nrf2 pathway in zebrafish.
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spelling pubmed-73475792020-07-10 Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish He, Ting Li, Xiao Wang, Xiaoping Xu, Xiao Yan, Xin Li, Xiang Sun, Siqi Dong, Ying Ren, Xueyang Liu, Xiaoyun Wang, Yu Sui, Hong Xia, Qing She, Gaimei Sci Rep Article Chemical profile and antioxidant potency of essential oils (EOs) of Thymus quinquecostatus Celak. (thyme oils) obtained from Loess Plateau in China had been studied. 130 constituents of thyme oils were determined using gas chromatography-mass spectrometry (GC–MS) and carvacrol ethyl ether was firstly reported as a new natural product, which has been used as a synthetic flavoring substance with no safety concern. The thyme oils showed the anti-oxidant activity using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) and conferred protection against oxidative stress in zebrafish. In addition, a class of carvacrol analogues was found to develop as potential natural antioxidant products of thyme oils from Loess Plateau by the correlation analysis. YL-thyme oil performed the best antioxidant activity in this research, which could be recommended as preferred sources of thyme oils. Furthermore, YL-thyme oil exhibited a potent antioxidant capacity by reactive oxygen species (ROS) scavenging, enhancing the endogenous antioxidant system, inhibiting lipid peroxidation and activation of Keap1/Nrf2 pathway in zebrafish. Nature Publishing Group UK 2020-07-09 /pmc/articles/PMC7347579/ /pubmed/32647188 http://dx.doi.org/10.1038/s41598-020-68188-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleΓÇÖs Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleΓÇÖs Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
He, Ting
Li, Xiao
Wang, Xiaoping
Xu, Xiao
Yan, Xin
Li, Xiang
Sun, Siqi
Dong, Ying
Ren, Xueyang
Liu, Xiaoyun
Wang, Yu
Sui, Hong
Xia, Qing
She, Gaimei
Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title_full Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title_fullStr Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title_full_unstemmed Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title_short Chemical composition and anti-oxidant potential on essential oils of Thymus quinquecostatus Celak. from Loess Plateau in China, regulating Nrf2/Keap1 signaling pathway in zebrafish
title_sort chemical composition and anti-oxidant potential on essential oils of thymus quinquecostatus celak. from loess plateau in china, regulating nrf2/keap1 signaling pathway in zebrafish
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347579/
https://www.ncbi.nlm.nih.gov/pubmed/32647188
http://dx.doi.org/10.1038/s41598-020-68188-8
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