Cargando…

Therapeutic vaccine-mediated Gag-specific CD8(+) T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8(+) cells in simian immunodeficiency virus-infected macaques

Anti-retroviral therapy (ART) can inhibit HIV proliferation but not achieve virus eradication from HIV-infected individuals. Under ART-based HIV control, virus-specific CD8(+) T-cell responses are often reduced. Here, we investigated the impact of therapeutic vaccination inducing virus-specific CD8(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakamura-Hoshi, Midori, Takahara, Yusuke, Matsuoka, Saori, Ishii, Hiroshi, Seki, Sayuri, Nomura, Takushi, Yamamoto, Hiroyuki, Sakawaki, Hiromi, Miura, Tomoyuki, Tokusumi, Tsuyoshi, Shu, Tsugumine, Matano, Tetsuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347614/ https://www.ncbi.nlm.nih.gov/pubmed/32647227 http://dx.doi.org/10.1038/s41598-020-68267-w

Ejemplares similares

Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8(+) T cells but not CD4(+) T cells
por: Ishii, Hiroshi, et al.
Publicado: (2022)

A Novel Protective MHC-I Haplotype Not Associated with Dominant Gag-Specific CD8(+) T-Cell Responses in SIVmac239 Infection of Burmese Rhesus Macaques
por: Takahashi, Naofumi, et al.
Publicado: (2013)

HTLV-1 Proliferation after CD8(+) Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques
por: Nakamura-Hoshi, Midori, et al.
Publicado: (2023)

Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model
por: Ishii, Hiroshi, et al.
Publicado: (2016)

CD8 T Cells Show Protection against Highly Pathogenic Simian Immunodeficiency Virus (SIV) after Vaccination with SIV Gene-Expressing BCG Prime and Vaccinia Virus/Sendai Virus Vector Boosts
por: Kato, Seiichi, et al.
Publicado: (2021)

Broadening of Virus-Specific CD8(+) T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers
por: Nomura, Takushi, et al.
Publicado: (2015)

Kunjin replicon-based simian immunodeficiency virus gag vaccines
por: Anraku, Itaru, et al.
Publicado: (2008)

Microbial Dysbiosis During Simian Immunodeficiency Virus Infection is Partially Reverted with Combination Anti-retroviral Therapy
por: Blum, Faith C., et al.
Publicado: (2020)

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques
por: Nomura, Takushi, et al.
Publicado: (2021)

In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts
por: Seki, Sayuri, et al.
Publicado: (2017)

Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11
por: Van Rompay, Koen KA, et al.
Publicado: (2006)

Dramatic Rise in Plasma Viremia after CD8(+) T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
por: Jin, Xia, et al.
Publicado: (1999)

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8(+) T cell responses
por: Ishii, Hiroshi, et al.
Publicado: (2022)

New insights into retroviral Gag–Gag and Gag–membrane interactions
por: Maldonado, José O., et al.
Publicado: (2014)

Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection
por: Loh, Liyen, et al.
Publicado: (2009)

Effects of in Vivo Cd8(+) T Cell Depletion on Virus Replication in Rhesus Macaques Immunized with a Live, Attenuated Simian Immunodeficiency Virus Vaccine
por: Metzner, Karin J., et al.
Publicado: (2000)

Agonistic Anti-CD40 Enhances the CD8(+) T Cell Response during Vesicular Stomatitis Virus Infection
por: Zickovich, Julianne M., et al.
Publicado: (2014)

Epitope specificity appears to be an important determinant of in vivo killing ability of simian immunodeficiency virus (SIV)-specific CD8+ T Cells
por: Pozzi, L, et al.
Publicado: (2012)

Acute-Phase CD8 T Cell Responses That Select for Escape Variants Are Needed to Control Live Attenuated Simian Immunodeficiency Virus
por: Harris, Max, et al.
Publicado: (2013)

Vaccination of rhesus monkeys with synthetic peptide in a fusogenic proteoliposome elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes
Publicado: (1992)

P17-19. Impact of single epitope-specific CD8+ T cell memory induction by prophylactic vaccination on immunodeficiency virus control
por: Tsukamoto, T, et al.
Publicado: (2009)

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+ T cell activation and killing of virus infected cells
por: Kløverpris, HN, et al.
Publicado: (2012)

Membrane interaction of retroviral Gag proteins
por: Dick, Robert A., et al.
Publicado: (2014)

Mutations in CD8 that affect interactions with HLA class I and monoclonal anti-CD8 antibodies
Publicado: (1991)

Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies
por: Clement, Mathew, et al.
Publicado: (2016)

Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8(+) and CD4(+)CD8(+) T Cells
por: De Pelsmaeker, Steffi, et al.
Publicado: (2019)

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody
Publicado: (1995)

Studies on feline CD8(+) T cell non-cytolytic anti-feline immunodeficiency virus (FIV) activity
por: Hohdatsu, T., et al.
Publicado: (2000)

CD8(+) Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels
por: Tsukamoto, Tetsuo, et al.
Publicado: (2019)

Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells
por: Cross, Eric W., et al.
Publicado: (2019)

Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity
por: Shinoda, Koji, et al.
Publicado: (2023)

IL-12-conditioning improves retrovirally-mediated transduction efficiency of CD8(+) T cells
por: Andrijauskaite, Kristina, et al.
Publicado: (2015)

High Production Rates Sustain In Vivo Levels of PD-1(high) Simian Immunodeficiency Virus-Specific CD8 T Cells in the Face of Rapid Clearance
por: Petrovas, Constantinos, et al.
Publicado: (2013)

Induction of neutralizing antibodies against tier 2 human immunodeficiency virus 1 in rhesus macaques infected with tier 1B simian/human immunodeficiency virus
por: Himeno, Ai, et al.
Publicado: (2019)

Upregulation of neuroreceptors on CD4+ and CD8+ T cells promotes their anti-tumor function
por: de Aquino, Maria Teresa, et al.
Publicado: (2015)

CD8+CD39+ T Cells Mediate Anti-Tumor Cytotoxicity in Bladder Cancer
por: Zhu, Wenjie, et al.
Publicado: (2021)

CD8α(2) CD11b(+) Dendritic Cells Present Exogenous Virus-like Particles to CD8(+) T Cells and Subsequently Express CD8α and CD205 Molecules
por: Morón, Gabriel, et al.
Publicado: (2002)

CD8 and CD4 T Cells in West Nile Virus Immunity and Pathogenesis
por: Netland, Jason, et al.
Publicado: (2013)

The CD8 T Cell Response to Respiratory Virus Infections
por: Schmidt, Megan E., et al.
Publicado: (2018)

Pigs that recover from porcine reproduction and respiratory syndrome virus infection develop cytotoxic CD4(+)CD8(+) and CD4(+)CD8(-) T-cells that kill virus infected cells
por: Chung, Chungwon J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_m4bvfc9qg8ngbr2b4oe4p3n40l