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The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future

Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limi...

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Autores principales: Zhang, Sainan, Yang, Ya, Fan, Linxiao, Zhang, Fen, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347776/
https://www.ncbi.nlm.nih.gov/pubmed/32775366
http://dx.doi.org/10.21037/atm.2020.03.218
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author Zhang, Sainan
Yang, Ya
Fan, Linxiao
Zhang, Fen
Li, Lanjuan
author_facet Zhang, Sainan
Yang, Ya
Fan, Linxiao
Zhang, Fen
Li, Lanjuan
author_sort Zhang, Sainan
collection PubMed
description Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limited by the shortage of honor organs and high cost. Nowadays, stem cell therapy gained more and more attention due to its attractive efficacy in treating liver disease especially in cirrhosis during the clinical trials. Mesenchymal stem cell (MSC) can be differentiated into hepatocytes, promote liver regeneration, inhibit liver fibrosis and induce liver apoptosis, particularly via paracrine mechanisms. This review will highlight recent clinical applications of MSC, providing the available evidence and discussing some unsolved questions in treating liver disease.
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spelling pubmed-73477762020-08-07 The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future Zhang, Sainan Yang, Ya Fan, Linxiao Zhang, Fen Li, Lanjuan Ann Transl Med Review Article on Stem Cell and Clinical Application Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limited by the shortage of honor organs and high cost. Nowadays, stem cell therapy gained more and more attention due to its attractive efficacy in treating liver disease especially in cirrhosis during the clinical trials. Mesenchymal stem cell (MSC) can be differentiated into hepatocytes, promote liver regeneration, inhibit liver fibrosis and induce liver apoptosis, particularly via paracrine mechanisms. This review will highlight recent clinical applications of MSC, providing the available evidence and discussing some unsolved questions in treating liver disease. AME Publishing Company 2020-04 /pmc/articles/PMC7347776/ /pubmed/32775366 http://dx.doi.org/10.21037/atm.2020.03.218 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article on Stem Cell and Clinical Application
Zhang, Sainan
Yang, Ya
Fan, Linxiao
Zhang, Fen
Li, Lanjuan
The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title_full The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title_fullStr The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title_full_unstemmed The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title_short The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
title_sort clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
topic Review Article on Stem Cell and Clinical Application
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347776/
https://www.ncbi.nlm.nih.gov/pubmed/32775366
http://dx.doi.org/10.21037/atm.2020.03.218
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