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The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future
Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347776/ https://www.ncbi.nlm.nih.gov/pubmed/32775366 http://dx.doi.org/10.21037/atm.2020.03.218 |
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author | Zhang, Sainan Yang, Ya Fan, Linxiao Zhang, Fen Li, Lanjuan |
author_facet | Zhang, Sainan Yang, Ya Fan, Linxiao Zhang, Fen Li, Lanjuan |
author_sort | Zhang, Sainan |
collection | PubMed |
description | Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limited by the shortage of honor organs and high cost. Nowadays, stem cell therapy gained more and more attention due to its attractive efficacy in treating liver disease especially in cirrhosis during the clinical trials. Mesenchymal stem cell (MSC) can be differentiated into hepatocytes, promote liver regeneration, inhibit liver fibrosis and induce liver apoptosis, particularly via paracrine mechanisms. This review will highlight recent clinical applications of MSC, providing the available evidence and discussing some unsolved questions in treating liver disease. |
format | Online Article Text |
id | pubmed-7347776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-73477762020-08-07 The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future Zhang, Sainan Yang, Ya Fan, Linxiao Zhang, Fen Li, Lanjuan Ann Transl Med Review Article on Stem Cell and Clinical Application Liver disease is a major health issue which present poor clinical treatment performance. Cirrhosis and liver failure are common clinical manifestations of liver diseases. Liver transplantation is recognized as the ultimate and most efficient therapy to the end stage of liver disease. But it was limited by the shortage of honor organs and high cost. Nowadays, stem cell therapy gained more and more attention due to its attractive efficacy in treating liver disease especially in cirrhosis during the clinical trials. Mesenchymal stem cell (MSC) can be differentiated into hepatocytes, promote liver regeneration, inhibit liver fibrosis and induce liver apoptosis, particularly via paracrine mechanisms. This review will highlight recent clinical applications of MSC, providing the available evidence and discussing some unsolved questions in treating liver disease. AME Publishing Company 2020-04 /pmc/articles/PMC7347776/ /pubmed/32775366 http://dx.doi.org/10.21037/atm.2020.03.218 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article on Stem Cell and Clinical Application Zhang, Sainan Yang, Ya Fan, Linxiao Zhang, Fen Li, Lanjuan The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title | The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title_full | The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title_fullStr | The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title_full_unstemmed | The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title_short | The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
title_sort | clinical application of mesenchymal stem cells in liver disease: the current situation and potential future |
topic | Review Article on Stem Cell and Clinical Application |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347776/ https://www.ncbi.nlm.nih.gov/pubmed/32775366 http://dx.doi.org/10.21037/atm.2020.03.218 |
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