Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8–MCM9 complex and compromises DNA mismatch repair in cancer cells

HORMAD1 is a meiosis-specific protein that promotes synapsis and recombination of homologous chromosomes in meiotic prophase. Originally identified as a cancer/testis antigen, HORMAD1 is also aberrantly expressed in several cancers. However, the functions of HORMAD1 in cancer cells are still not cle...

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Detalles Bibliográficos
Autores principales: Liu, Kang, Wang, Yifan, Zhu, Quanfeng, Li, Peng, Chen, Jiyuan, Tang, Zhenghui, Shen, Yuanming, Cheng, Xiaodong, Lu, Lin-Yu, Liu, Yidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347845/
https://www.ncbi.nlm.nih.gov/pubmed/32647118
http://dx.doi.org/10.1038/s41419-020-2736-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347845/
https://www.ncbi.nlm.nih.gov/pubmed/32647118
http://dx.doi.org/10.1038/s41419-020-2736-1

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