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Adult pancreatoblastoma: clinical features and Imaging findings

The objective of this study was to illustrate the clinical, CT, MRI, and (18)F-FDG PET/CT features of adult pancreatoblastoma, an extremely rare disease. In this study, the clinical and imaging features of seven adult patients with pathologically confirmed pancreatoblastoma were retrospectively anal...

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Autores principales: Zhang, Xi, Ni, Shu-juan, Wang, Xiao-hong, Huang, Dan, Tang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347875/
https://www.ncbi.nlm.nih.gov/pubmed/32647222
http://dx.doi.org/10.1038/s41598-020-68083-2
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author Zhang, Xi
Ni, Shu-juan
Wang, Xiao-hong
Huang, Dan
Tang, Wei
author_facet Zhang, Xi
Ni, Shu-juan
Wang, Xiao-hong
Huang, Dan
Tang, Wei
author_sort Zhang, Xi
collection PubMed
description The objective of this study was to illustrate the clinical, CT, MRI, and (18)F-FDG PET/CT features of adult pancreatoblastoma, an extremely rare disease. In this study, the clinical and imaging features of seven adult patients with pathologically confirmed pancreatoblastoma were retrospectively analyzed. The following parameters were evaluated: size, location, shape, margination, solid-cystic ratio, CT attenuation values or signal intensity and contrast enhancement pattern. We also analyzed whether abnormal FDG uptake occurred during (18)F-FDG PET/CT imaging. All seven patients were male (mean age 45 years; range 22–65 years). Six tumors were irregular in shape, exogenous, and grew outward from the pancreatic parenchyma, similar to branches growing from a tree trunk (85.7%). The tumor margins were clear in five patients (71.4%), and three tumors (42.9%) were encapsulated. Six tumors (71.4%) were solid, with homogeneous enhancement observed on contrast-enhanced CT and MRI. Dynamic-enhanced CT and MRI showed progressive enhancement for all tumors. On (18)F-FDG PET/CT, one tumor exhibited abnormal FDG uptake, and two tumors exhibited no abnormal uptake (66.7%). In conclusion, adult pancreatoblastoma most commonly occurs in male patients, and it usually appears as an exophytic, irregular, and hypovascular mass with well-defined margins and progressive enhancement on CT and MRI. This type of tumor always grows out of the parenchyma of the pancreas, similar to branches growing outward from a tree trunk.
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spelling pubmed-73478752020-07-14 Adult pancreatoblastoma: clinical features and Imaging findings Zhang, Xi Ni, Shu-juan Wang, Xiao-hong Huang, Dan Tang, Wei Sci Rep Article The objective of this study was to illustrate the clinical, CT, MRI, and (18)F-FDG PET/CT features of adult pancreatoblastoma, an extremely rare disease. In this study, the clinical and imaging features of seven adult patients with pathologically confirmed pancreatoblastoma were retrospectively analyzed. The following parameters were evaluated: size, location, shape, margination, solid-cystic ratio, CT attenuation values or signal intensity and contrast enhancement pattern. We also analyzed whether abnormal FDG uptake occurred during (18)F-FDG PET/CT imaging. All seven patients were male (mean age 45 years; range 22–65 years). Six tumors were irregular in shape, exogenous, and grew outward from the pancreatic parenchyma, similar to branches growing from a tree trunk (85.7%). The tumor margins were clear in five patients (71.4%), and three tumors (42.9%) were encapsulated. Six tumors (71.4%) were solid, with homogeneous enhancement observed on contrast-enhanced CT and MRI. Dynamic-enhanced CT and MRI showed progressive enhancement for all tumors. On (18)F-FDG PET/CT, one tumor exhibited abnormal FDG uptake, and two tumors exhibited no abnormal uptake (66.7%). In conclusion, adult pancreatoblastoma most commonly occurs in male patients, and it usually appears as an exophytic, irregular, and hypovascular mass with well-defined margins and progressive enhancement on CT and MRI. This type of tumor always grows out of the parenchyma of the pancreas, similar to branches growing outward from a tree trunk. Nature Publishing Group UK 2020-07-09 /pmc/articles/PMC7347875/ /pubmed/32647222 http://dx.doi.org/10.1038/s41598-020-68083-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Xi
Ni, Shu-juan
Wang, Xiao-hong
Huang, Dan
Tang, Wei
Adult pancreatoblastoma: clinical features and Imaging findings
title Adult pancreatoblastoma: clinical features and Imaging findings
title_full Adult pancreatoblastoma: clinical features and Imaging findings
title_fullStr Adult pancreatoblastoma: clinical features and Imaging findings
title_full_unstemmed Adult pancreatoblastoma: clinical features and Imaging findings
title_short Adult pancreatoblastoma: clinical features and Imaging findings
title_sort adult pancreatoblastoma: clinical features and imaging findings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347875/
https://www.ncbi.nlm.nih.gov/pubmed/32647222
http://dx.doi.org/10.1038/s41598-020-68083-2
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