Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (LNP) as a vaccine. We observe remarkably hi...

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Detalles Bibliográficos
Autores principales: McKay, Paul F., Hu, Kai, Blakney, Anna K., Samnuan, Karnyart, Brown, Jonathan C., Penn, Rebecca, Zhou, Jie, Bouton, Clément R., Rogers, Paul, Polra, Krunal, Lin, Paulo J. C., Barbosa, Christopher, Tam, Ying K., Barclay, Wendy S., Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347890/
https://www.ncbi.nlm.nih.gov/pubmed/32647131
http://dx.doi.org/10.1038/s41467-020-17409-9

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