STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation

Elucidating the contribution of somatic mutations to cancer is essential for personalized medicine. STK11 (LKB1) appears to be inactivated in human cancer. However, somatic missense mutations also occur, and the role/s of these alterations to this disease remain unknown. Here, we investigated the co...

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Detalles Bibliográficos
Autores principales: Granado-Martínez, Paula, Garcia-Ortega, Sara, González-Sánchez, Elena, McGrail, Kimberley, Selgas, Rafael, Grueso, Judit, Gil, Rosa, Naldaiz-Gastesi, Neia, Rhodes, Ana C., Hernandez-Losa, Javier, Ferrer, Berta, Canals, Francesc, Villanueva, Josep, Méndez, Olga, Espinosa-Gil, Sergio, Lizcano, José M., Muñoz-Couselo, Eva, García-Patos, Vicenç, Recio, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347935/
https://www.ncbi.nlm.nih.gov/pubmed/32647375
http://dx.doi.org/10.1038/s42003-020-1092-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347935/
https://www.ncbi.nlm.nih.gov/pubmed/32647375
http://dx.doi.org/10.1038/s42003-020-1092-0

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