Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

The interaction of prion protein (PrP) and α-synuclein (αSyn) oligomers causes synaptic impairment that might trigger Parkinson’s disease and other synucleinopathies. Here, we report that αSyn oligomers (αSynO) cluster with human PrP (huPrP) into micron-sized condensates. Multivalency of αSyn within...

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Detalles Bibliográficos
Autores principales: Rösener, Nadine S., Gremer, Lothar, Wördehoff, Michael M., Kupreichyk, Tatsiana, Etzkorn, Manuel, Neudecker, Philipp, Hoyer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347944/
https://www.ncbi.nlm.nih.gov/pubmed/32647130
http://dx.doi.org/10.1038/s42003-020-1085-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347944/
https://www.ncbi.nlm.nih.gov/pubmed/32647130
http://dx.doi.org/10.1038/s42003-020-1085-z

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