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OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not completely understood. The translocation of ATGL, a critical lip...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348002/ https://www.ncbi.nlm.nih.gov/pubmed/32650117 http://dx.doi.org/10.1016/j.isci.2020.101252 |
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author | Wang, Tianming Wei, Qinjun Liang, Lihong Tang, Xujun Yao, Jun Lu, Yajie Qu, Yuan Chen, Zhibin Xing, Guangqian Cao, Xin |
author_facet | Wang, Tianming Wei, Qinjun Liang, Lihong Tang, Xujun Yao, Jun Lu, Yajie Qu, Yuan Chen, Zhibin Xing, Guangqian Cao, Xin |
author_sort | Wang, Tianming |
collection | PubMed |
description | The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not completely understood. The translocation of ATGL, a critical lipolysis lipase, from the ER to the LD surface is mediated by an energy catabolism complex. Oxysterol-binding protein-like 2 (OSBPL2/ORP2) is one of the lipid transfer proteins that regulates intracellular cholesterol homeostasis. A recent study has proven that Osbpl2(−/−) pigs exhibit hypercholesterolemia and obesity phenotypes with an increase in adipocytes. In this study, we identified that OSBPL2 links the endoplasmic reticulum (ER) with LDs, binds to COPB1, and mediates ATGL transport. We provide important insights into the function of OSBPL2, indicating that it is required for the regulation of lipid droplet lipolysis. |
format | Online Article Text |
id | pubmed-7348002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73480022020-07-14 OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis Wang, Tianming Wei, Qinjun Liang, Lihong Tang, Xujun Yao, Jun Lu, Yajie Qu, Yuan Chen, Zhibin Xing, Guangqian Cao, Xin iScience Article The accumulation of giant lipid droplets (LDs) increases the risk of metabolic disorders including obesity and insulin resistance. The lipolysis process involves the activation and transfer of lipase, but the molecular mechanism is not completely understood. The translocation of ATGL, a critical lipolysis lipase, from the ER to the LD surface is mediated by an energy catabolism complex. Oxysterol-binding protein-like 2 (OSBPL2/ORP2) is one of the lipid transfer proteins that regulates intracellular cholesterol homeostasis. A recent study has proven that Osbpl2(−/−) pigs exhibit hypercholesterolemia and obesity phenotypes with an increase in adipocytes. In this study, we identified that OSBPL2 links the endoplasmic reticulum (ER) with LDs, binds to COPB1, and mediates ATGL transport. We provide important insights into the function of OSBPL2, indicating that it is required for the regulation of lipid droplet lipolysis. Elsevier 2020-06-20 /pmc/articles/PMC7348002/ /pubmed/32650117 http://dx.doi.org/10.1016/j.isci.2020.101252 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Tianming Wei, Qinjun Liang, Lihong Tang, Xujun Yao, Jun Lu, Yajie Qu, Yuan Chen, Zhibin Xing, Guangqian Cao, Xin OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title_full | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title_fullStr | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title_full_unstemmed | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title_short | OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis |
title_sort | osbpl2 is required for the binding of copb1 to atgl and the regulation of lipid droplet lipolysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348002/ https://www.ncbi.nlm.nih.gov/pubmed/32650117 http://dx.doi.org/10.1016/j.isci.2020.101252 |
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