重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析

OBJECTIVE: To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA). METHODS: Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gen...

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Detalles Bibliográficos
Autor principal: Mamal, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial office of Chinese Journal of Hematology 2017
Materias:
论著
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348355/
https://www.ncbi.nlm.nih.gov/pubmed/29081192
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.09.006
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author Mamal, A
author_facet Mamal, A
collection PubMed
description OBJECTIVE: To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA). METHODS: Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gender, interval to transplantation, the level of serum ferritin before transplantation were analyzed by Cox multivariate regression analysis. RESULTS: Among the 111 patients who underwent allo-HSCT, 16 developed PGF (14.4%). Multivariate analysis showed donor type (HR=2.656, 95%CI 1.204–5.858, P= 0.016) and the level of serum ferritin before tansplantation (HR=3.170, 95%CI 1.400–7.180, P=0.006) were significant risk factors for PGF. CONCLUSION: Unrelated donor transplantation and the high level of serum ferritin before transplantation are risk factors for PGF.
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spelling pubmed-73483552020-07-16 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析 Mamal, A Zhonghua Xue Ye Xue Za Zhi 论著 OBJECTIVE: To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA). METHODS: Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gender, interval to transplantation, the level of serum ferritin before transplantation were analyzed by Cox multivariate regression analysis. RESULTS: Among the 111 patients who underwent allo-HSCT, 16 developed PGF (14.4%). Multivariate analysis showed donor type (HR=2.656, 95%CI 1.204–5.858, P= 0.016) and the level of serum ferritin before tansplantation (HR=3.170, 95%CI 1.400–7.180, P=0.006) were significant risk factors for PGF. CONCLUSION: Unrelated donor transplantation and the high level of serum ferritin before transplantation are risk factors for PGF. Editorial office of Chinese Journal of Hematology 2017-09 /pmc/articles/PMC7348355/ /pubmed/29081192 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.09.006 Text en 2017年版权归中华医学会所有 http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution 3.0 License (CC-BY-NC). The Copyright own by Publisher. Without authorization, shall not reprint, except this publication article, shall not use this publication format design. Unless otherwise stated, all articles published in this journal do not represent the views of the Chinese Medical Association or the editorial board of this journal.
spellingShingle 论著
Mamal, A
重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title_full 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title_fullStr 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title_full_unstemmed 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title_short 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
title_sort 重型再生障碍性贫血行异基因造血干细胞移植后植入功能不良的危险因素分析
topic 论著
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348355/
https://www.ncbi.nlm.nih.gov/pubmed/29081192
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2017.09.006
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