化疗前不同抑郁程度对非M(3)型急性髓系白血病患者调节性T细胞的影响

OBJECTIVE: To investigate the influence of depression levels on regulatory T cells (Tregs) in patients with non-M(3) acute myeloid leukemia (AML). METHODS: A total of 63 patients with primarily diagnostic non-M(3) AML and 25 healthy controls were enrolled, and the levels of depression by using HADM score and the percentages of Tregs by flow cytometry were evaluated in pre-treatment and post-treatment, respectively. RESULTS: After every course of chemotherapy, the percentages of Tregs of PBMNC in AML showed the higher level of (6.48±1.81)% than those of (4.99±1.29)% in control (P= 0.001). There was no difference among different levels of depression groups after the first cycle. However, the percentages of Tregs increased with the worse of depression after the second and third cycles. Partial correlation analysis after adjusting age indicated that the percentages of Tregs showed no correlation with the levels of depression after the first cycle (correlation coefficient, 0.120, P=0.345), and showed the positive correlation with depression levels after the second and third cycles (correlation coefficient, 0.619 and 0.614, all P values <0.05). CONCLUSION: The depression levels showed an association with the percentages of Tregs in patients with non-M(3) AML, which could be observed only after the second cycles of chemotherapy.