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Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis

Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total...

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Autores principales: Zhu, Yixin, Lu, Tong, Xie, Chunming, Wang, Qing, Wang, Yanjuan, Cao, Xuejin, Su, Yuting, Wang, Zan, Zhang, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348592/
https://www.ncbi.nlm.nih.gov/pubmed/32719596
http://dx.doi.org/10.3389/fnagi.2020.00203
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author Zhu, Yixin
Lu, Tong
Xie, Chunming
Wang, Qing
Wang, Yanjuan
Cao, Xuejin
Su, Yuting
Wang, Zan
Zhang, Zhijun
author_facet Zhu, Yixin
Lu, Tong
Xie, Chunming
Wang, Qing
Wang, Yanjuan
Cao, Xuejin
Su, Yuting
Wang, Zan
Zhang, Zhijun
author_sort Zhu, Yixin
collection PubMed
description Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total of 36 patients with ILA (Fazekas rating score ≥2) and 31 healthy controls (HCs) underwent comprehensive neuropsychological assessments (covering four cognitive domains, i.e., information processing speed, episodic memory, executive and visuospatial function) and resting-state functional MRI scans. Graph theory-based analyses were employed to explore the topological organization of the brain connectome in ILA patients, and we further sought to explore the associations of connectome-based metrics and neuropsychological performances. An efficient small-world architecture in the functional brain connectome was observed in the ILA and control groups. Moreover, compared with the HCs, the ILA patients showed increased path length and decreased network efficiency (i.e., global and local efficiency) in their functional brain networks. Further network-based statistic (NBS) analysis revealed a functional-disconnected network in ILA, which is comprised of functional connections linking different brain modules (i.e., default mode, frontoparietal, ventral attention and limbic systems) and connections within single modules (i.e., ventral attention and limbic systems). Intriguingly, the abnormal network metrics correlated with cognitive deficits in ILA patients. Therefore, our findings provide further evidence to support the concept that ILA pathologies could disrupt brain connections, impairing network functioning, and cognition via a “disconnection syndrome.”
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spelling pubmed-73485922020-07-26 Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis Zhu, Yixin Lu, Tong Xie, Chunming Wang, Qing Wang, Yanjuan Cao, Xuejin Su, Yuting Wang, Zan Zhang, Zhijun Front Aging Neurosci Neuroscience Cognitive impairment is a key clinical feature of ischemic leukoaraiosis (ILA); however, the underlying neurobiological mechanism is still unclear. ILA has been associated with widespread gray and white matter (WM) damage mainly located in cortical-cortical and cortico-subcortical pathways. A total of 36 patients with ILA (Fazekas rating score ≥2) and 31 healthy controls (HCs) underwent comprehensive neuropsychological assessments (covering four cognitive domains, i.e., information processing speed, episodic memory, executive and visuospatial function) and resting-state functional MRI scans. Graph theory-based analyses were employed to explore the topological organization of the brain connectome in ILA patients, and we further sought to explore the associations of connectome-based metrics and neuropsychological performances. An efficient small-world architecture in the functional brain connectome was observed in the ILA and control groups. Moreover, compared with the HCs, the ILA patients showed increased path length and decreased network efficiency (i.e., global and local efficiency) in their functional brain networks. Further network-based statistic (NBS) analysis revealed a functional-disconnected network in ILA, which is comprised of functional connections linking different brain modules (i.e., default mode, frontoparietal, ventral attention and limbic systems) and connections within single modules (i.e., ventral attention and limbic systems). Intriguingly, the abnormal network metrics correlated with cognitive deficits in ILA patients. Therefore, our findings provide further evidence to support the concept that ILA pathologies could disrupt brain connections, impairing network functioning, and cognition via a “disconnection syndrome.” Frontiers Media S.A. 2020-07-03 /pmc/articles/PMC7348592/ /pubmed/32719596 http://dx.doi.org/10.3389/fnagi.2020.00203 Text en Copyright © 2020 Zhu, Lu, Xie, Wang, Wang, Cao, Su, Wang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhu, Yixin
Lu, Tong
Xie, Chunming
Wang, Qing
Wang, Yanjuan
Cao, Xuejin
Su, Yuting
Wang, Zan
Zhang, Zhijun
Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title_full Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title_fullStr Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title_full_unstemmed Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title_short Functional Disorganization of Small-World Brain Networks in Patients With Ischemic Leukoaraiosis
title_sort functional disorganization of small-world brain networks in patients with ischemic leukoaraiosis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348592/
https://www.ncbi.nlm.nih.gov/pubmed/32719596
http://dx.doi.org/10.3389/fnagi.2020.00203
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