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IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

Aging is a major risk factor for Alzheimer’s disease (AD). Insulin-like growth factor-1 receptor (IGF-1R) regulates general aging and lifespan. However, the contribution of IGF-1 to age-related AD pathology and progression is highly controversial. Based on our previous work, AβPP/PS1 double transgen...

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Detalles Bibliográficos
Autores principales:	Sohrabi, Mona, Floden, Angela M., Manocha, Gunjan D., Klug, Marilyn G., Combs, Colin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cellular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348663/ https://www.ncbi.nlm.nih.gov/pubmed/32719587 http://dx.doi.org/10.3389/fncel.2020.00200

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