Cargando…

Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL

NOTCH signaling represents a promising therapeutic target in chronic lymphocytic leukemia (CLL). We compared the anti-neoplastic effects of the nuclear NOTCH2 inhibitor gliotoxin and the pan-NOTCH γ-secretase inhibitor RO4929097 in primary CLL cells with special emphasis on the individual roles of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hubmann, Rainer, Schnabl, Susanne, Araghi, Mohammad, Schmidl, Christian, Rendeiro, André F., Hilgarth, Martin, Demirtas, Dita, Ali, Farghaly, Staber, Philipp B., Valent, Peter, Zielinski, Christoph, Jäger, Ulrich, Shehata, Medhat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348714/ https://www.ncbi.nlm.nih.gov/pubmed/32570839 http://dx.doi.org/10.3390/cells9061484

Ejemplares similares

Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model
por: Hubmann, Rainer, et al.
Publicado: (2017)

Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy
por: Kamdje, A H Nwabo, et al.
Publicado: (2012)

Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells
por: López-Guerra, Mónica, et al.
Publicado: (2019)

UGT2B17 modifies drug response in chronic lymphocytic leukaemia
por: Allain, Eric P., et al.
Publicado: (2020)

Oncogenic and tumor suppressor functions of Notch in cancer: it’s NOTCH what you think
por: Lobry, Camille, et al.
Publicado: (2011)

Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin
por: Schrettl, Markus, et al.
Publicado: (2010)

Tumor suppressors revival in CLL
por: Carrà, Giovanna, et al.
Publicado: (2017)

Notch signaling in lung diseases: focus on Notch1 and Notch3
por: Zong, Dandan, et al.
Publicado: (2016)

Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation
por: Freund, Patricia, et al.
Publicado: (2016)

Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity
por: Smith, Elizabeth B., et al.
Publicado: (2016)

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL
por: De Falco, Filomena, et al.
Publicado: (2015)

Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial
por: Larrayoz, M, et al.
Publicado: (2017)

Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in mice
por: Sugui, Janyce A., et al.
Publicado: (2017)

A novel tumor suppressor function for the Notch pathway in myeloid leukemia
por: Klinakis, Apostolos, et al.
Publicado: (2011)

NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
por: Huang, Tingting, et al.
Publicado: (2016)

To Be, Notch to Be
por: De, Moumita, et al.
Publicado: (2020)

Effect of gliotoxin on human polymorphonuclear neutrophils.
por: Shah, D T, et al.
Publicado: (1998)

The adhesion force of Notch with Delta and the rate of Notch signaling
por: Ahimou, Francois, et al.
Publicado: (2004)

Notching on Cancer’s Door: Notch Signaling in Brain Tumors
por: Teodorczyk, Marcin, et al.
Publicado: (2015)

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL
por: De Falco, Filomena, et al.
Publicado: (2022)

NOTCH1 Intracellular Domain and the Tumor Microenvironment as Prognostic Markers in HNSCC
por: Schmidl, Benedikt, et al.
Publicado: (2022)

Top notch /
por: Saslow, Joan M.
Publicado: (2011)

Phased by Notch
por: Van Epps, Heather L.
Publicado: (2005)

Notched Teeth
Publicado: (1883)

Notched Teeth
Publicado: (1883)

The Role of Zinc in Gliotoxin Biosynthesis of Aspergillus fumigatus
por: Seo, Hyewon, et al.
Publicado: (2019)

Regulation of gliotoxin biosynthesis and protection in Aspergillus species
por: de Castro, Patrícia Alves, et al.
Publicado: (2022)

The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
por: Xu, Peng, et al.
Publicado: (2013)

Kick it up a notch: Notch signaling and kidney fibrosis
por: Sweetwyne, Mariya T, et al.
Publicado: (2014)

The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
por: Harbuzariu, Adriana, et al.
Publicado: (2018)

Temporal Notch activation through Notch1a and Notch3 is required for maintaining zebrafish rhombomere boundaries
por: Qiu, Xuehui, et al.
Publicado: (2009)

A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers
por: Chen, Daipeng, et al.
Publicado: (2023)

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
por: Rendeiro, André F., et al.
Publicado: (2020)

Is miR-29 an oncogene or tumor suppressor in CLL?
por: Pekarsky, Yuri, et al.
Publicado: (2010)

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
por: van Es, Johan H., et al.
Publicado: (2010)

Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis
por: Böttcher, Martin, et al.
Publicado: (2021)

Necking and notch strengthening in metallic glass with symmetric sharp-and-deep notches
por: Sha, Z. D., et al.
Publicado: (2015)

Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus
por: Shawber, Carrie J., et al.
Publicado: (2015)

Retraction: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
Publicado: (2019)

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
por: Hounjet, Judith, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0agk268iergmkt0bu5ssnfqtte