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Centering and Shifting of Centrosomes in Cells
Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348834/ https://www.ncbi.nlm.nih.gov/pubmed/32485978 http://dx.doi.org/10.3390/cells9061351 |
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author | Burakov, Anton V. Nadezhdina, Elena S. |
author_facet | Burakov, Anton V. Nadezhdina, Elena S. |
author_sort | Burakov, Anton V. |
collection | PubMed |
description | Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primary cilia. This review discusses centrosome placement options in cultured and in situ cells. It has been proven that the central arrangement of centrosomes is due mainly to the pulling microtubules forces developed by dynein located on the cell cortex and intracellular vesicles. The pushing forces from dynamic microtubules and actomyosin also contribute, although the molecular mechanisms of their action have not yet been elucidated. Centrosomal displacement is caused by external cues, depending on signaling, and is drawn through the redistribution of dynein, the asymmetrization of microtubules through the capture of their plus ends, and the redistribution of actomyosin, which, in turn, is associated with basal-apical cell polarization. |
format | Online Article Text |
id | pubmed-7348834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73488342020-07-22 Centering and Shifting of Centrosomes in Cells Burakov, Anton V. Nadezhdina, Elena S. Cells Review Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primary cilia. This review discusses centrosome placement options in cultured and in situ cells. It has been proven that the central arrangement of centrosomes is due mainly to the pulling microtubules forces developed by dynein located on the cell cortex and intracellular vesicles. The pushing forces from dynamic microtubules and actomyosin also contribute, although the molecular mechanisms of their action have not yet been elucidated. Centrosomal displacement is caused by external cues, depending on signaling, and is drawn through the redistribution of dynein, the asymmetrization of microtubules through the capture of their plus ends, and the redistribution of actomyosin, which, in turn, is associated with basal-apical cell polarization. MDPI 2020-05-29 /pmc/articles/PMC7348834/ /pubmed/32485978 http://dx.doi.org/10.3390/cells9061351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Burakov, Anton V. Nadezhdina, Elena S. Centering and Shifting of Centrosomes in Cells |
title | Centering and Shifting of Centrosomes in Cells |
title_full | Centering and Shifting of Centrosomes in Cells |
title_fullStr | Centering and Shifting of Centrosomes in Cells |
title_full_unstemmed | Centering and Shifting of Centrosomes in Cells |
title_short | Centering and Shifting of Centrosomes in Cells |
title_sort | centering and shifting of centrosomes in cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348834/ https://www.ncbi.nlm.nih.gov/pubmed/32485978 http://dx.doi.org/10.3390/cells9061351 |
work_keys_str_mv | AT burakovantonv centeringandshiftingofcentrosomesincells AT nadezhdinaelenas centeringandshiftingofcentrosomesincells |