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Centering and Shifting of Centrosomes in Cells

Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primar...

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Detalles Bibliográficos
Autores principales: Burakov, Anton V., Nadezhdina, Elena S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348834/
https://www.ncbi.nlm.nih.gov/pubmed/32485978
http://dx.doi.org/10.3390/cells9061351
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author Burakov, Anton V.
Nadezhdina, Elena S.
author_facet Burakov, Anton V.
Nadezhdina, Elena S.
author_sort Burakov, Anton V.
collection PubMed
description Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primary cilia. This review discusses centrosome placement options in cultured and in situ cells. It has been proven that the central arrangement of centrosomes is due mainly to the pulling microtubules forces developed by dynein located on the cell cortex and intracellular vesicles. The pushing forces from dynamic microtubules and actomyosin also contribute, although the molecular mechanisms of their action have not yet been elucidated. Centrosomal displacement is caused by external cues, depending on signaling, and is drawn through the redistribution of dynein, the asymmetrization of microtubules through the capture of their plus ends, and the redistribution of actomyosin, which, in turn, is associated with basal-apical cell polarization.
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spelling pubmed-73488342020-07-22 Centering and Shifting of Centrosomes in Cells Burakov, Anton V. Nadezhdina, Elena S. Cells Review Centrosomes have a nonrandom localization in the cells: either they occupy the centroid of the zone free of the actomyosin cortex or they are shifted to the edge of the cell, where their presence is justified from a functional point of view, for example, to organize additional microtubules or primary cilia. This review discusses centrosome placement options in cultured and in situ cells. It has been proven that the central arrangement of centrosomes is due mainly to the pulling microtubules forces developed by dynein located on the cell cortex and intracellular vesicles. The pushing forces from dynamic microtubules and actomyosin also contribute, although the molecular mechanisms of their action have not yet been elucidated. Centrosomal displacement is caused by external cues, depending on signaling, and is drawn through the redistribution of dynein, the asymmetrization of microtubules through the capture of their plus ends, and the redistribution of actomyosin, which, in turn, is associated with basal-apical cell polarization. MDPI 2020-05-29 /pmc/articles/PMC7348834/ /pubmed/32485978 http://dx.doi.org/10.3390/cells9061351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burakov, Anton V.
Nadezhdina, Elena S.
Centering and Shifting of Centrosomes in Cells
title Centering and Shifting of Centrosomes in Cells
title_full Centering and Shifting of Centrosomes in Cells
title_fullStr Centering and Shifting of Centrosomes in Cells
title_full_unstemmed Centering and Shifting of Centrosomes in Cells
title_short Centering and Shifting of Centrosomes in Cells
title_sort centering and shifting of centrosomes in cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348834/
https://www.ncbi.nlm.nih.gov/pubmed/32485978
http://dx.doi.org/10.3390/cells9061351
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