Cargando…

Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice

Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Kang, Guo, Yannan, Ping, Lu, Qiu, Ying, Liu, Qingfei, Li, Zhongchi, Wang, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348883/
https://www.ncbi.nlm.nih.gov/pubmed/32580272
http://dx.doi.org/10.3390/cells9061513
_version_ 1783556934666813440
author Xu, Kang
Guo, Yannan
Ping, Lu
Qiu, Ying
Liu, Qingfei
Li, Zhongchi
Wang, Zhao
author_facet Xu, Kang
Guo, Yannan
Ping, Lu
Qiu, Ying
Liu, Qingfei
Li, Zhongchi
Wang, Zhao
author_sort Xu, Kang
collection PubMed
description Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis remains unknown. Here, in vivo results demonstrated that SIRT6 overexpression attenuates DSS-induced colitis in terms of clinical manifestations, histopathological damage, loss of tight junction function and imbalanced intestinal microenvironment. Additionally, we also found that the activation of NF-κB and c-Jun induced by DSS is diminished by SIRT6 overexpression. Furthermore, SIRT6 may regulate TAK1 to inhibit NF-κB and c-Jun signaling. Thus, our findings highlight the protective effect of SIRT6 on colon, further supporting the perspective that SIRT6 may be a therapeutic target for intestine injury under stress.
format Online
Article
Text
id pubmed-7348883
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73488832020-07-22 Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice Xu, Kang Guo, Yannan Ping, Lu Qiu, Ying Liu, Qingfei Li, Zhongchi Wang, Zhao Cells Article Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis remains unknown. Here, in vivo results demonstrated that SIRT6 overexpression attenuates DSS-induced colitis in terms of clinical manifestations, histopathological damage, loss of tight junction function and imbalanced intestinal microenvironment. Additionally, we also found that the activation of NF-κB and c-Jun induced by DSS is diminished by SIRT6 overexpression. Furthermore, SIRT6 may regulate TAK1 to inhibit NF-κB and c-Jun signaling. Thus, our findings highlight the protective effect of SIRT6 on colon, further supporting the perspective that SIRT6 may be a therapeutic target for intestine injury under stress. MDPI 2020-06-22 /pmc/articles/PMC7348883/ /pubmed/32580272 http://dx.doi.org/10.3390/cells9061513 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Kang
Guo, Yannan
Ping, Lu
Qiu, Ying
Liu, Qingfei
Li, Zhongchi
Wang, Zhao
Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title_full Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title_fullStr Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title_full_unstemmed Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title_short Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice
title_sort protective effects of sirt6 overexpression against dss-induced colitis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348883/
https://www.ncbi.nlm.nih.gov/pubmed/32580272
http://dx.doi.org/10.3390/cells9061513
work_keys_str_mv AT xukang protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT guoyannan protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT pinglu protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT qiuying protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT liuqingfei protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT lizhongchi protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice
AT wangzhao protectiveeffectsofsirt6overexpressionagainstdssinducedcolitisinmice