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Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice
Zika Virus (ZIKV) is transmitted primarily by Aedes aegypti mosquitoes, resulting in asymptomatic infection, or acute illness with a fever and headache, or neurological complications, such as Guillain-Barre syndrome or fetal microcephaly. Previously, we determined that AgBR1, a mosquito salivary pro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348886/ https://www.ncbi.nlm.nih.gov/pubmed/32218189 http://dx.doi.org/10.3390/vaccines8020145 |
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author | Wang, Yuchen Marin-Lopez, Alejandro Jiang, Junjun Ledizet, Michel Fikrig, Erol |
author_facet | Wang, Yuchen Marin-Lopez, Alejandro Jiang, Junjun Ledizet, Michel Fikrig, Erol |
author_sort | Wang, Yuchen |
collection | PubMed |
description | Zika Virus (ZIKV) is transmitted primarily by Aedes aegypti mosquitoes, resulting in asymptomatic infection, or acute illness with a fever and headache, or neurological complications, such as Guillain-Barre syndrome or fetal microcephaly. Previously, we determined that AgBR1, a mosquito salivary protein, induces inflammatory responses at the bite site, and that passive immunization with AgBR1 antiserum influences mosquito-transmitted ZIKV infection. Here, we show that the active immunization of mice with AgBR1 adjuvanted with aluminum hydroxide delays lethal mosquito-borne ZIKV infection, suggesting that AgBR1 may be used as part of a vaccine to combat ZIKV. |
format | Online Article Text |
id | pubmed-7348886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73488862020-07-22 Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice Wang, Yuchen Marin-Lopez, Alejandro Jiang, Junjun Ledizet, Michel Fikrig, Erol Vaccines (Basel) Article Zika Virus (ZIKV) is transmitted primarily by Aedes aegypti mosquitoes, resulting in asymptomatic infection, or acute illness with a fever and headache, or neurological complications, such as Guillain-Barre syndrome or fetal microcephaly. Previously, we determined that AgBR1, a mosquito salivary protein, induces inflammatory responses at the bite site, and that passive immunization with AgBR1 antiserum influences mosquito-transmitted ZIKV infection. Here, we show that the active immunization of mice with AgBR1 adjuvanted with aluminum hydroxide delays lethal mosquito-borne ZIKV infection, suggesting that AgBR1 may be used as part of a vaccine to combat ZIKV. MDPI 2020-03-25 /pmc/articles/PMC7348886/ /pubmed/32218189 http://dx.doi.org/10.3390/vaccines8020145 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Yuchen Marin-Lopez, Alejandro Jiang, Junjun Ledizet, Michel Fikrig, Erol Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title | Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title_full | Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title_fullStr | Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title_full_unstemmed | Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title_short | Vaccination with Aedes aegypti AgBR1 Delays Lethal Mosquito-Borne Zika Virus Infection in Mice |
title_sort | vaccination with aedes aegypti agbr1 delays lethal mosquito-borne zika virus infection in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348886/ https://www.ncbi.nlm.nih.gov/pubmed/32218189 http://dx.doi.org/10.3390/vaccines8020145 |
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