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Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract

There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house si...

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Autores principales: Lee, Jaewon J., Kopetz, Scott, Vilar, Eduardo, Shen, John Paul, Chen, Ken, Maitra, Anirban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349178/
https://www.ncbi.nlm.nih.gov/pubmed/32545271
http://dx.doi.org/10.3390/genes11060645
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author Lee, Jaewon J.
Kopetz, Scott
Vilar, Eduardo
Shen, John Paul
Chen, Ken
Maitra, Anirban
author_facet Lee, Jaewon J.
Kopetz, Scott
Vilar, Eduardo
Shen, John Paul
Chen, Ken
Maitra, Anirban
author_sort Lee, Jaewon J.
collection PubMed
description There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.
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spelling pubmed-73491782020-07-22 Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract Lee, Jaewon J. Kopetz, Scott Vilar, Eduardo Shen, John Paul Chen, Ken Maitra, Anirban Genes (Basel) Brief Report There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection. MDPI 2020-06-11 /pmc/articles/PMC7349178/ /pubmed/32545271 http://dx.doi.org/10.3390/genes11060645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Lee, Jaewon J.
Kopetz, Scott
Vilar, Eduardo
Shen, John Paul
Chen, Ken
Maitra, Anirban
Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title_full Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title_fullStr Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title_full_unstemmed Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title_short Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
title_sort relative abundance of sars-cov-2 entry genes in the enterocytes of the lower gastrointestinal tract
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349178/
https://www.ncbi.nlm.nih.gov/pubmed/32545271
http://dx.doi.org/10.3390/genes11060645
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