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Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house si...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349178/ https://www.ncbi.nlm.nih.gov/pubmed/32545271 http://dx.doi.org/10.3390/genes11060645 |
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author | Lee, Jaewon J. Kopetz, Scott Vilar, Eduardo Shen, John Paul Chen, Ken Maitra, Anirban |
author_facet | Lee, Jaewon J. Kopetz, Scott Vilar, Eduardo Shen, John Paul Chen, Ken Maitra, Anirban |
author_sort | Lee, Jaewon J. |
collection | PubMed |
description | There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection. |
format | Online Article Text |
id | pubmed-7349178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73491782020-07-22 Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract Lee, Jaewon J. Kopetz, Scott Vilar, Eduardo Shen, John Paul Chen, Ken Maitra, Anirban Genes (Basel) Brief Report There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection. MDPI 2020-06-11 /pmc/articles/PMC7349178/ /pubmed/32545271 http://dx.doi.org/10.3390/genes11060645 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Lee, Jaewon J. Kopetz, Scott Vilar, Eduardo Shen, John Paul Chen, Ken Maitra, Anirban Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title | Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title_full | Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title_fullStr | Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title_full_unstemmed | Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title_short | Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract |
title_sort | relative abundance of sars-cov-2 entry genes in the enterocytes of the lower gastrointestinal tract |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349178/ https://www.ncbi.nlm.nih.gov/pubmed/32545271 http://dx.doi.org/10.3390/genes11060645 |
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