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Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species
Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or peop...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349190/ https://www.ncbi.nlm.nih.gov/pubmed/32719819 http://dx.doi.org/10.3389/fvets.2020.00457 |
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author | Cao, Ying Sun, Yeping Tian, Xiaodong Bai, Zhihua Gong, Yue Qi, Jianxun Liu, Di Liu, Wenjun Li, Jing |
author_facet | Cao, Ying Sun, Yeping Tian, Xiaodong Bai, Zhihua Gong, Yue Qi, Jianxun Liu, Di Liu, Wenjun Li, Jing |
author_sort | Cao, Ying |
collection | PubMed |
description | Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or people with potential chronic diseases or in immunosuppressive states. According to big data analysis, there are many proteins homologous to or interacting with the angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be the only receptor for the novel coronavirus; other receptors may also exist in host cells of different species. These potential receptors may also play an important role in the infection process of the novel coronavirus. The current study aimed to discover such key proteins or receptors and analyze the susceptibility of different animals to the novel coronavirus, in order to reveal the transmission process of the virus in cross-species infection. We analyzed the proteins coded by the ACE2 gene in different mammalian species and predicted their correlation and homology with the human ACE2 receptor. The major finding of our predictive analysis suggested ACE2 gene-encoded proteins to be highly homologous across mammals. Based on their high homology, their possibility of binding the spike-protein of SARS-CoV-2 is quite high and species such as Felis catus, Bos taurus, Rattus norvegicus etc. may be potential susceptible hosts; special monitoring is particularly required for livestock that are in close contact with humans. Our results might provide ideas for the prevention and control of the novel coronavirus pneumonia. |
format | Online Article Text |
id | pubmed-7349190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73491902020-07-26 Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species Cao, Ying Sun, Yeping Tian, Xiaodong Bai, Zhihua Gong, Yue Qi, Jianxun Liu, Di Liu, Wenjun Li, Jing Front Vet Sci Veterinary Science Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or people with potential chronic diseases or in immunosuppressive states. According to big data analysis, there are many proteins homologous to or interacting with the angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be the only receptor for the novel coronavirus; other receptors may also exist in host cells of different species. These potential receptors may also play an important role in the infection process of the novel coronavirus. The current study aimed to discover such key proteins or receptors and analyze the susceptibility of different animals to the novel coronavirus, in order to reveal the transmission process of the virus in cross-species infection. We analyzed the proteins coded by the ACE2 gene in different mammalian species and predicted their correlation and homology with the human ACE2 receptor. The major finding of our predictive analysis suggested ACE2 gene-encoded proteins to be highly homologous across mammals. Based on their high homology, their possibility of binding the spike-protein of SARS-CoV-2 is quite high and species such as Felis catus, Bos taurus, Rattus norvegicus etc. may be potential susceptible hosts; special monitoring is particularly required for livestock that are in close contact with humans. Our results might provide ideas for the prevention and control of the novel coronavirus pneumonia. Frontiers Media S.A. 2020-07-03 /pmc/articles/PMC7349190/ /pubmed/32719819 http://dx.doi.org/10.3389/fvets.2020.00457 Text en Copyright © 2020 Cao, Sun, Tian, Bai, Gong, Qi, Liu, Liu and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Cao, Ying Sun, Yeping Tian, Xiaodong Bai, Zhihua Gong, Yue Qi, Jianxun Liu, Di Liu, Wenjun Li, Jing Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title | Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title_full | Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title_fullStr | Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title_full_unstemmed | Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title_short | Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species |
title_sort | analysis of ace2 gene-encoded proteins across mammalian species |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349190/ https://www.ncbi.nlm.nih.gov/pubmed/32719819 http://dx.doi.org/10.3389/fvets.2020.00457 |
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