Cargando…

RELMα Is Induced in Airway Epithelial Cells by Oncostatin M without Requirement of STAT6 or IL-6 in Mouse Lungs In Vivo

Resistin-like molecule alpha (RELMα) and YM-1 are secreted proteins implicated in murine models of alternatively activated macrophage (AA/M2) accumulation and Th2-skewed inflammation. Since the gp130 cytokine Oncostatin M (OSM) induces a Th2-like cytokine and AA/M2 skewed inflammation in mouse lung,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Lilian, Yip, Ashley, Lao, Francis, Botelho, Fernando, Richards, Carl D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349350/ https://www.ncbi.nlm.nih.gov/pubmed/32471168 http://dx.doi.org/10.3390/cells9061338

Ejemplares similares

IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M
por: Botelho, Fernando, et al.
Publicado: (2020)

Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells
por: Richards, Carl D., et al.
Publicado: (2016)

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716
por: RICHARDS, Carl D., et al.
Publicado: (2020)

Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M
por: Kwofie, Karen, et al.
Publicado: (2015)

Oncostatin M in the Regulation of Connective Tissue Cells and Macrophages in Pulmonary Disease
por: Richards, Carl D., et al.
Publicado: (2019)

The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD
por: Che, Li, et al.
Publicado: (2021)

Human resistin and the RELM of Inflammation in diabesity
por: Al Hannan, Fatima, et al.
Publicado: (2015)

LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia
por: Li, Yu, et al.
Publicado: (2021)

Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells
por: Schnittker, David, et al.
Publicado: (2013)

The Enigmatic Cytokine Oncostatin M and Roles in Disease
por: Richards, Carl D.
Publicado: (2013)

Adenoviral transfer of murine OncostatinM induces inflammation and bone apposition in joints of IL-1, IL-6 and TNF-α deficient mice
por: de Hooge, ASK, et al.
Publicado: (2002)

Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps
por: Carsuzaa, Florent, et al.
Publicado: (2023)

Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection
por: Herbert, De'Broski R., et al.
Publicado: (2009)

Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection
por: Ghorbani, Peyman, et al.
Publicado: (2023)

Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M
por: Botelho, Fernando M., et al.
Publicado: (2019)

IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse
por: Oike, Takatsugu, et al.
Publicado: (2018)

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
por: Zhao, Hedi, et al.
Publicado: (2019)

Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages
por: Forman, Ruth, et al.
Publicado: (2021)

IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1
por: Wu, Wan-Ju, et al.
Publicado: (2021)

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection
por: Sutherland, Tara E., et al.
Publicado: (2018)

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils
por: Li, Jiang, et al.
Publicado: (2023)

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils
por: Li, Jiang, et al.
Publicado: (2023)

Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways
por: Kurosawa, Tamaki, et al.
Publicado: (2015)

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4
por: Vella, Anthony, et al.
Publicado: (1997)

Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway
por: Yang, Ruhui, et al.
Publicado: (2020)

Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction
por: Bequignon, Emilie, et al.
Publicado: (2020)

IL-6-STAT3 signaling and premature senescence
por: Kojima, Hirotada, et al.
Publicado: (2013)

E2F1/SP3/STAT6 axis is required for IL-4-induced epithelial-mesenchymal transition of colorectal cancer cells
por: Chen, Jiaoe, et al.
Publicado: (2018)

High expression of RELM-α correlates with poor prognosis and promotes angiogenesis in gastric cancer
por: Chen, Ping, et al.
Publicado: (2019)

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines
por: Fossey, Stacey L, et al.
Publicado: (2011)

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling
por: van Krieken, Pim P., et al.
Publicado: (2021)

Dual STAT-3 and IL-6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL-6/IL-6R/STAT-3 axis
por: Méndez-Clemente, Anibal, et al.
Publicado: (2022)

Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma
por: Jia, Changchang, et al.
Publicado: (2020)

B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema
por: Chen, Fei, et al.
Publicado: (2018)

Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis
por: Han, Liang, et al.
Publicado: (2023)

Fingolimod inhibits proliferation and epithelial–mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
por: Wang, Jiaqi, et al.
Publicado: (2020)

RHOJ Induces Epithelial-to-Mesenchymal Transition by IL-6/STAT3 to Promote Invasion and Metastasis in Gastric Cancer
por: Ma, Zhijie, et al.
Publicado: (2023)

Goblet Cell Derived RELM-β Recruits CD4(+) T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation
por: Bergstrom, Kirk S. B., et al.
Publicado: (2015)

Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members
por: Beigel, Florian, et al.
Publicado: (2014)

Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
por: Pesce, John T., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_bjictpns0i7mvprv0at6ck1b3u