The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation

NSIAD is a rare X-linked condition, caused by activating mutations in the AVPR2 gene coding for the vasopressin V2 receptor (V2R) associated with hyponatremia, despite undetectable plasma vasopressin levels. We have recently provided in vitro evidence that, compared to V2R-wt, expression of activati...

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Detalles Bibliográficos
Autores principales: Ranieri, Marianna, Venneri, Maria, Pellegrino, Tommaso, Centrone, Mariangela, Di Mise, Annarita, Cotecchia, Susanna, Tamma, Grazia, Valenti, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349359/
https://www.ncbi.nlm.nih.gov/pubmed/32486031
http://dx.doi.org/10.3390/cells9061354

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