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CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulatin...

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Detalles Bibliográficos
Autores principales: Liang, Shujing, Hu, Lifang, Wu, Zixiang, Chen, Zhihao, Liu, Shuyu, Xu, Xia, Qian, Airong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349380/
https://www.ncbi.nlm.nih.gov/pubmed/32570740
http://dx.doi.org/10.3390/cells9061483
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author Liang, Shujing
Hu, Lifang
Wu, Zixiang
Chen, Zhihao
Liu, Shuyu
Xu, Xia
Qian, Airong
author_facet Liang, Shujing
Hu, Lifang
Wu, Zixiang
Chen, Zhihao
Liu, Shuyu
Xu, Xia
Qian, Airong
author_sort Liang, Shujing
collection PubMed
description Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy.
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spelling pubmed-73493802020-07-22 CDK12: A Potent Target and Biomarker for Human Cancer Therapy Liang, Shujing Hu, Lifang Wu, Zixiang Chen, Zhihao Liu, Shuyu Xu, Xia Qian, Airong Cells Review Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy. MDPI 2020-06-18 /pmc/articles/PMC7349380/ /pubmed/32570740 http://dx.doi.org/10.3390/cells9061483 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liang, Shujing
Hu, Lifang
Wu, Zixiang
Chen, Zhihao
Liu, Shuyu
Xu, Xia
Qian, Airong
CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title_full CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title_fullStr CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title_full_unstemmed CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title_short CDK12: A Potent Target and Biomarker for Human Cancer Therapy
title_sort cdk12: a potent target and biomarker for human cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349380/
https://www.ncbi.nlm.nih.gov/pubmed/32570740
http://dx.doi.org/10.3390/cells9061483
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