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CDK12: A Potent Target and Biomarker for Human Cancer Therapy
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulatin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349380/ https://www.ncbi.nlm.nih.gov/pubmed/32570740 http://dx.doi.org/10.3390/cells9061483 |
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author | Liang, Shujing Hu, Lifang Wu, Zixiang Chen, Zhihao Liu, Shuyu Xu, Xia Qian, Airong |
author_facet | Liang, Shujing Hu, Lifang Wu, Zixiang Chen, Zhihao Liu, Shuyu Xu, Xia Qian, Airong |
author_sort | Liang, Shujing |
collection | PubMed |
description | Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy. |
format | Online Article Text |
id | pubmed-7349380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73493802020-07-22 CDK12: A Potent Target and Biomarker for Human Cancer Therapy Liang, Shujing Hu, Lifang Wu, Zixiang Chen, Zhihao Liu, Shuyu Xu, Xia Qian, Airong Cells Review Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12′s biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy. MDPI 2020-06-18 /pmc/articles/PMC7349380/ /pubmed/32570740 http://dx.doi.org/10.3390/cells9061483 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liang, Shujing Hu, Lifang Wu, Zixiang Chen, Zhihao Liu, Shuyu Xu, Xia Qian, Airong CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title | CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title_full | CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title_fullStr | CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title_full_unstemmed | CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title_short | CDK12: A Potent Target and Biomarker for Human Cancer Therapy |
title_sort | cdk12: a potent target and biomarker for human cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349380/ https://www.ncbi.nlm.nih.gov/pubmed/32570740 http://dx.doi.org/10.3390/cells9061483 |
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