Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production

Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major. As iron is a critical factor in Fe-S cluster assembly that is absolutely required for the metabolic fun...

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Detalles Bibliográficos
Autores principales: Fiorillo, Marco, Tóth, Fanni, Brindisi, Matteo, Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349387/
https://www.ncbi.nlm.nih.gov/pubmed/32585919
http://dx.doi.org/10.3390/cells9061529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349387/
https://www.ncbi.nlm.nih.gov/pubmed/32585919
http://dx.doi.org/10.3390/cells9061529

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