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Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience

Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other elementary lesions are frequently observed, configuring a series of different pathological pictures. In this article, we review the pathological findings of...

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Autores principales: Luigetti, Marco, Romano, Angela, Di Paolantonio, Andrea, Bisogni, Giulia, Rossi, Salvatore, Conte, Amelia, Madia, Francesca, Sabatelli, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349397/
https://www.ncbi.nlm.nih.gov/pubmed/32560468
http://dx.doi.org/10.3390/brainsci10060383
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author Luigetti, Marco
Romano, Angela
Di Paolantonio, Andrea
Bisogni, Giulia
Rossi, Salvatore
Conte, Amelia
Madia, Francesca
Sabatelli, Mario
author_facet Luigetti, Marco
Romano, Angela
Di Paolantonio, Andrea
Bisogni, Giulia
Rossi, Salvatore
Conte, Amelia
Madia, Francesca
Sabatelli, Mario
author_sort Luigetti, Marco
collection PubMed
description Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other elementary lesions are frequently observed, configuring a series of different pathological pictures. In this article, we review the pathological findings of a large series of sural nerve biopsies from our cohort of CIDP patients. Patients and Methods: Patients with CIDP who underwent nerve biopsy were retrospectively selected from those referred to the Institute of Neurology of the “Università Cattolica del Sacro Cuore” in Rome, Italy, from 1982 to February 2020. Sural nerve biopsy was performed according to standard protocols. Results: Sural nerve biopsy was performed in 43/130 CIDP patients. Demyelinating abnormalities and axonal loss were found in 67.4% and 83.7% of biopsies, respectively. Conversely, onion bulbs and inflammatory infiltrates were rare (18.6% and 4.7%, respectively). In three cases, we observed normal pathological findings. Conclusions: A pathognomonic pathological finding of CIDP cannot be established, but we confirm the utility of nerve biopsy in this setting to confirm the diagnosis (also in atypical phenotypes) and to elucidate pathogenic mechanisms.
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spelling pubmed-73493972020-07-22 Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience Luigetti, Marco Romano, Angela Di Paolantonio, Andrea Bisogni, Giulia Rossi, Salvatore Conte, Amelia Madia, Francesca Sabatelli, Mario Brain Sci Article Objective: Segmental demyelination is the pathological hallmark of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but other elementary lesions are frequently observed, configuring a series of different pathological pictures. In this article, we review the pathological findings of a large series of sural nerve biopsies from our cohort of CIDP patients. Patients and Methods: Patients with CIDP who underwent nerve biopsy were retrospectively selected from those referred to the Institute of Neurology of the “Università Cattolica del Sacro Cuore” in Rome, Italy, from 1982 to February 2020. Sural nerve biopsy was performed according to standard protocols. Results: Sural nerve biopsy was performed in 43/130 CIDP patients. Demyelinating abnormalities and axonal loss were found in 67.4% and 83.7% of biopsies, respectively. Conversely, onion bulbs and inflammatory infiltrates were rare (18.6% and 4.7%, respectively). In three cases, we observed normal pathological findings. Conclusions: A pathognomonic pathological finding of CIDP cannot be established, but we confirm the utility of nerve biopsy in this setting to confirm the diagnosis (also in atypical phenotypes) and to elucidate pathogenic mechanisms. MDPI 2020-06-17 /pmc/articles/PMC7349397/ /pubmed/32560468 http://dx.doi.org/10.3390/brainsci10060383 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luigetti, Marco
Romano, Angela
Di Paolantonio, Andrea
Bisogni, Giulia
Rossi, Salvatore
Conte, Amelia
Madia, Francesca
Sabatelli, Mario
Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title_full Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title_fullStr Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title_full_unstemmed Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title_short Pathological Findings in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Single-Center Experience
title_sort pathological findings in chronic inflammatory demyelinating polyradiculoneuropathy: a single-center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349397/
https://www.ncbi.nlm.nih.gov/pubmed/32560468
http://dx.doi.org/10.3390/brainsci10060383
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