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Application of Genetically Engineered Pigs in Biomedical Research
Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic anima...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349405/ https://www.ncbi.nlm.nih.gov/pubmed/32575461 http://dx.doi.org/10.3390/genes11060670 |
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author | Hryhorowicz, Magdalena Lipiński, Daniel Hryhorowicz, Szymon Nowak-Terpiłowska, Agnieszka Ryczek, Natalia Zeyland, Joanna |
author_facet | Hryhorowicz, Magdalena Lipiński, Daniel Hryhorowicz, Szymon Nowak-Terpiłowska, Agnieszka Ryczek, Natalia Zeyland, Joanna |
author_sort | Hryhorowicz, Magdalena |
collection | PubMed |
description | Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic animal species is not only aimed towards accelerating traditional breeding programs and improving animal health and the quality of animal products for consumption but can also be used in biomedicine. Animal studies are conducted to develop models used in gene function and regulation research and the genetic determinants of certain human diseases. Another direction of research, described in this review, focuses on the use of transgenic animals as a source of high-quality biopharmaceuticals, such as recombinant proteins. The further aspect discussed is the use of genetically modified animals as a source of cells, tissues, and organs for transplantation into human recipients, i.e., xenotransplantation. Numerous studies have shown that the pig (Sus scrofa domestica) is the most suitable species both as a research model for human diseases and as an optimal organ donor for xenotransplantation. Short pregnancy, short generation interval, and high litter size make the production of transgenic pigs less time-consuming in comparison with other livestock species This review describes genetically modified pigs used for biomedical research and the future challenges and perspectives for the use of the swine animal models. |
format | Online Article Text |
id | pubmed-7349405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73494052020-07-14 Application of Genetically Engineered Pigs in Biomedical Research Hryhorowicz, Magdalena Lipiński, Daniel Hryhorowicz, Szymon Nowak-Terpiłowska, Agnieszka Ryczek, Natalia Zeyland, Joanna Genes (Basel) Review Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic animal species is not only aimed towards accelerating traditional breeding programs and improving animal health and the quality of animal products for consumption but can also be used in biomedicine. Animal studies are conducted to develop models used in gene function and regulation research and the genetic determinants of certain human diseases. Another direction of research, described in this review, focuses on the use of transgenic animals as a source of high-quality biopharmaceuticals, such as recombinant proteins. The further aspect discussed is the use of genetically modified animals as a source of cells, tissues, and organs for transplantation into human recipients, i.e., xenotransplantation. Numerous studies have shown that the pig (Sus scrofa domestica) is the most suitable species both as a research model for human diseases and as an optimal organ donor for xenotransplantation. Short pregnancy, short generation interval, and high litter size make the production of transgenic pigs less time-consuming in comparison with other livestock species This review describes genetically modified pigs used for biomedical research and the future challenges and perspectives for the use of the swine animal models. MDPI 2020-06-19 /pmc/articles/PMC7349405/ /pubmed/32575461 http://dx.doi.org/10.3390/genes11060670 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hryhorowicz, Magdalena Lipiński, Daniel Hryhorowicz, Szymon Nowak-Terpiłowska, Agnieszka Ryczek, Natalia Zeyland, Joanna Application of Genetically Engineered Pigs in Biomedical Research |
title | Application of Genetically Engineered Pigs in Biomedical Research |
title_full | Application of Genetically Engineered Pigs in Biomedical Research |
title_fullStr | Application of Genetically Engineered Pigs in Biomedical Research |
title_full_unstemmed | Application of Genetically Engineered Pigs in Biomedical Research |
title_short | Application of Genetically Engineered Pigs in Biomedical Research |
title_sort | application of genetically engineered pigs in biomedical research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349405/ https://www.ncbi.nlm.nih.gov/pubmed/32575461 http://dx.doi.org/10.3390/genes11060670 |
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