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Chaperones and Proteostasis: Role in Parkinson’s Disease
Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stres...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349525/ https://www.ncbi.nlm.nih.gov/pubmed/32580484 http://dx.doi.org/10.3390/diseases8020024 |
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author | Joshi, Neha Raveendran, Atchaya Nagotu, Shirisha |
author_facet | Joshi, Neha Raveendran, Atchaya Nagotu, Shirisha |
author_sort | Joshi, Neha |
collection | PubMed |
description | Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stress conditions is a major contributing factor for the formation of these toxic aggregates. A conserved class of proteins called chaperones and co-chaperones is implicated in maintaining the cellular protein homeostasis. Expanding the body of evidence highlights the role of chaperones as central mediators in the formation, de-aggregation and degradation of the aggregates. Altered expression and function of chaperones is associated with many neurodegenerative diseases including Parkinson’s disease. Several studies indicate that chaperones are at the center of the cause and effect cycle of this disease. An overview of the various chaperones that are associated with homeostasis of Parkinson’s disease-related proteins and their role in pathogenicity will be discussed in this review. |
format | Online Article Text |
id | pubmed-7349525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73495252020-07-14 Chaperones and Proteostasis: Role in Parkinson’s Disease Joshi, Neha Raveendran, Atchaya Nagotu, Shirisha Diseases Review Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders. Loss of protein homeostasis triggered by cellular stress conditions is a major contributing factor for the formation of these toxic aggregates. A conserved class of proteins called chaperones and co-chaperones is implicated in maintaining the cellular protein homeostasis. Expanding the body of evidence highlights the role of chaperones as central mediators in the formation, de-aggregation and degradation of the aggregates. Altered expression and function of chaperones is associated with many neurodegenerative diseases including Parkinson’s disease. Several studies indicate that chaperones are at the center of the cause and effect cycle of this disease. An overview of the various chaperones that are associated with homeostasis of Parkinson’s disease-related proteins and their role in pathogenicity will be discussed in this review. MDPI 2020-06-22 /pmc/articles/PMC7349525/ /pubmed/32580484 http://dx.doi.org/10.3390/diseases8020024 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Joshi, Neha Raveendran, Atchaya Nagotu, Shirisha Chaperones and Proteostasis: Role in Parkinson’s Disease |
title | Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_full | Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_fullStr | Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_full_unstemmed | Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_short | Chaperones and Proteostasis: Role in Parkinson’s Disease |
title_sort | chaperones and proteostasis: role in parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349525/ https://www.ncbi.nlm.nih.gov/pubmed/32580484 http://dx.doi.org/10.3390/diseases8020024 |
work_keys_str_mv | AT joshineha chaperonesandproteostasisroleinparkinsonsdisease AT raveendranatchaya chaperonesandproteostasisroleinparkinsonsdisease AT nagotushirisha chaperonesandproteostasisroleinparkinsonsdisease |