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Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities

Both the gut-brain axis (GBA) and the hypothalamic–pituitary–adrenal (HPA) axis remain an intriguing yet obscure network with a strong influence over other systems of organs. Recent reports have sought to describe the multitude of harmful stressors that may impact the HPA axis along with the interco...

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Autores principales: Simionescu, Gabriela, Ilie, Ovidiu-Dumitru, Ciobica, Alin, Doroftei, Bogdan, Maftei, Radu, Grab, Delia, McKenna, Jack, Dhunna, Nitasha, Mavroudis, Ioannis, Anton, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349587/
https://www.ncbi.nlm.nih.gov/pubmed/32560488
http://dx.doi.org/10.3390/brainsci10060384
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author Simionescu, Gabriela
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Doroftei, Bogdan
Maftei, Radu
Grab, Delia
McKenna, Jack
Dhunna, Nitasha
Mavroudis, Ioannis
Anton, Emil
author_facet Simionescu, Gabriela
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Doroftei, Bogdan
Maftei, Radu
Grab, Delia
McKenna, Jack
Dhunna, Nitasha
Mavroudis, Ioannis
Anton, Emil
author_sort Simionescu, Gabriela
collection PubMed
description Both the gut-brain axis (GBA) and the hypothalamic–pituitary–adrenal (HPA) axis remain an intriguing yet obscure network with a strong influence over other systems of organs. Recent reports have sought to describe the multitude of harmful stressors that may impact the HPA axis along with the interconnections between these. This has improved our knowledge of how the underlying mechanisms working to establish homeostasis are affected. A disruption to the HPA axis can amplify the chances of gastrointestinal deficiencies, whilst also increasing the risk of a wide spectrum of neuropsychiatric disorders. Thus, the influence of microorganisms found throughout the digestive tract possess the ability to affect both physiology and behaviour by triggering responses, which may be unfavourable. This is sometimes the case in of infertility. Numerous supplements have been formulated with the intention of rebalancing the gut microflora. Accordingly, the gut flora may alter the pharmacokinetics of drugs used as part of fertility treatments, potentially exacerbating the predisposition for various neurological disorders, regardless of the age and gender.
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spelling pubmed-73495872020-07-14 Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities Simionescu, Gabriela Ilie, Ovidiu-Dumitru Ciobica, Alin Doroftei, Bogdan Maftei, Radu Grab, Delia McKenna, Jack Dhunna, Nitasha Mavroudis, Ioannis Anton, Emil Brain Sci Review Both the gut-brain axis (GBA) and the hypothalamic–pituitary–adrenal (HPA) axis remain an intriguing yet obscure network with a strong influence over other systems of organs. Recent reports have sought to describe the multitude of harmful stressors that may impact the HPA axis along with the interconnections between these. This has improved our knowledge of how the underlying mechanisms working to establish homeostasis are affected. A disruption to the HPA axis can amplify the chances of gastrointestinal deficiencies, whilst also increasing the risk of a wide spectrum of neuropsychiatric disorders. Thus, the influence of microorganisms found throughout the digestive tract possess the ability to affect both physiology and behaviour by triggering responses, which may be unfavourable. This is sometimes the case in of infertility. Numerous supplements have been formulated with the intention of rebalancing the gut microflora. Accordingly, the gut flora may alter the pharmacokinetics of drugs used as part of fertility treatments, potentially exacerbating the predisposition for various neurological disorders, regardless of the age and gender. MDPI 2020-06-17 /pmc/articles/PMC7349587/ /pubmed/32560488 http://dx.doi.org/10.3390/brainsci10060384 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Simionescu, Gabriela
Ilie, Ovidiu-Dumitru
Ciobica, Alin
Doroftei, Bogdan
Maftei, Radu
Grab, Delia
McKenna, Jack
Dhunna, Nitasha
Mavroudis, Ioannis
Anton, Emil
Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title_full Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title_fullStr Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title_full_unstemmed Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title_short Mini-Review on the Possible Interconnections between the Gut-Brain Axis and the Infertility-Related Neuropsychiatric Comorbidities
title_sort mini-review on the possible interconnections between the gut-brain axis and the infertility-related neuropsychiatric comorbidities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349587/
https://www.ncbi.nlm.nih.gov/pubmed/32560488
http://dx.doi.org/10.3390/brainsci10060384
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