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G9a Is SETting the Stage for Colorectal Oncogenesis
Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe suc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349591/ https://www.ncbi.nlm.nih.gov/pubmed/32512705 http://dx.doi.org/10.3390/genes11060616 |
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author | Bergin, Christopher J. Benoit, Yannick D. |
author_facet | Bergin, Christopher J. Benoit, Yannick D. |
author_sort | Bergin, Christopher J. |
collection | PubMed |
description | Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness. |
format | Online Article Text |
id | pubmed-7349591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73495912020-07-14 G9a Is SETting the Stage for Colorectal Oncogenesis Bergin, Christopher J. Benoit, Yannick D. Genes (Basel) Perspective Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness. MDPI 2020-06-04 /pmc/articles/PMC7349591/ /pubmed/32512705 http://dx.doi.org/10.3390/genes11060616 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Bergin, Christopher J. Benoit, Yannick D. G9a Is SETting the Stage for Colorectal Oncogenesis |
title | G9a Is SETting the Stage for Colorectal Oncogenesis |
title_full | G9a Is SETting the Stage for Colorectal Oncogenesis |
title_fullStr | G9a Is SETting the Stage for Colorectal Oncogenesis |
title_full_unstemmed | G9a Is SETting the Stage for Colorectal Oncogenesis |
title_short | G9a Is SETting the Stage for Colorectal Oncogenesis |
title_sort | g9a is setting the stage for colorectal oncogenesis |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349591/ https://www.ncbi.nlm.nih.gov/pubmed/32512705 http://dx.doi.org/10.3390/genes11060616 |
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