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Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves

During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-t...

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Detalles Bibliográficos
Autores principales: Beta, Carsten, Gov, Nir S., Yochelis, Arik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349605/
https://www.ncbi.nlm.nih.gov/pubmed/32585983
http://dx.doi.org/10.3390/cells9061533
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author Beta, Carsten
Gov, Nir S.
Yochelis, Arik
author_facet Beta, Carsten
Gov, Nir S.
Yochelis, Arik
author_sort Beta, Carsten
collection PubMed
description During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator–inhibitor type and highlight the qualitative role of mass conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass conservation, and distinct behaviors of actin waves.
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spelling pubmed-73496052020-07-14 Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves Beta, Carsten Gov, Nir S. Yochelis, Arik Cells Perspective During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator–inhibitor type and highlight the qualitative role of mass conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass conservation, and distinct behaviors of actin waves. MDPI 2020-06-23 /pmc/articles/PMC7349605/ /pubmed/32585983 http://dx.doi.org/10.3390/cells9061533 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Beta, Carsten
Gov, Nir S.
Yochelis, Arik
Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title_full Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title_fullStr Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title_full_unstemmed Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title_short Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
title_sort why a large-scale mode can be essential for understanding intracellular actin waves
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349605/
https://www.ncbi.nlm.nih.gov/pubmed/32585983
http://dx.doi.org/10.3390/cells9061533
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