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Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves
During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349605/ https://www.ncbi.nlm.nih.gov/pubmed/32585983 http://dx.doi.org/10.3390/cells9061533 |
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author | Beta, Carsten Gov, Nir S. Yochelis, Arik |
author_facet | Beta, Carsten Gov, Nir S. Yochelis, Arik |
author_sort | Beta, Carsten |
collection | PubMed |
description | During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator–inhibitor type and highlight the qualitative role of mass conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass conservation, and distinct behaviors of actin waves. |
format | Online Article Text |
id | pubmed-7349605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73496052020-07-14 Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves Beta, Carsten Gov, Nir S. Yochelis, Arik Cells Perspective During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator–inhibitor type and highlight the qualitative role of mass conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass conservation, and distinct behaviors of actin waves. MDPI 2020-06-23 /pmc/articles/PMC7349605/ /pubmed/32585983 http://dx.doi.org/10.3390/cells9061533 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Beta, Carsten Gov, Nir S. Yochelis, Arik Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title | Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title_full | Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title_fullStr | Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title_full_unstemmed | Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title_short | Why a Large-Scale Mode Can Be Essential for Understanding Intracellular Actin Waves |
title_sort | why a large-scale mode can be essential for understanding intracellular actin waves |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349605/ https://www.ncbi.nlm.nih.gov/pubmed/32585983 http://dx.doi.org/10.3390/cells9061533 |
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