Desialylation of Sonic-Hedgehog by Neu2 Inhibits Its Association with Patched1 Reducing Stemness-Like Properties in Pancreatic Cancer Sphere-forming Cells

Cancer stem cells (CSCs) are crucial regulators of tumor recurrence/progression. The maintenance of CSCs is dependent on aberrant activation of various pathways, including Hedgehog. Prevalent sialylations contribute to aggressiveness in CSCs. Here, we have addressed the role of sialylation in regula...

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Detalles Bibliográficos
Autores principales: Nath, Shalini, Mondal, Susmita, Butti, Ramesh, Prasanna Gunasekaran, Vinoth, Chatterjee, Uttara, Halder, Aniket, Kundu, Gopal C., Mandal, Chitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349614/
https://www.ncbi.nlm.nih.gov/pubmed/32575925
http://dx.doi.org/10.3390/cells9061512

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