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CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

p21(Waf/CIP1) is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1 and G2 phases of the cell cycle. In the absence...

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Detalles Bibliográficos
Autores principales:	Mansilla, Sabrina Florencia, De La Vega, María Belén, Calzetta, Nicolás Luis, Siri, Sebastián Omar, Gottifredi, Vanesa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349641/ https://www.ncbi.nlm.nih.gov/pubmed/32481484 http://dx.doi.org/10.3390/genes11060593

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