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Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease

In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patien...

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Autores principales: Tan, Shennie, Hong, Chien Tai, Chen, Jia-Hung, Chan, Lung, Chi, Wen-Chou, Yen, Chia-Feng, Liao, Hua-Fang, Liou, Tsan-Hon, Wu, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349665/
https://www.ncbi.nlm.nih.gov/pubmed/32498218
http://dx.doi.org/10.3390/brainsci10060337
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author Tan, Shennie
Hong, Chien Tai
Chen, Jia-Hung
Chan, Lung
Chi, Wen-Chou
Yen, Chia-Feng
Liao, Hua-Fang
Liou, Tsan-Hon
Wu, Dean
author_facet Tan, Shennie
Hong, Chien Tai
Chen, Jia-Hung
Chan, Lung
Chi, Wen-Chou
Yen, Chia-Feng
Liao, Hua-Fang
Liou, Tsan-Hon
Wu, Dean
author_sort Tan, Shennie
collection PubMed
description In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patients with moderate-to-advanced PD. Moderate and advanced PD patients with and without dementia were identified from the Taiwan Data Bank of Persons with Disability. Hand fine motor capacities, namely pen holding, buttoning, and knotting, were assessed with the World Health Organization Disability Assessment Schedule 2.0. Statistical analyses were performed on Statistical Analysis System (SAS) and a p value of <0.05 was considered significant. In total, 3440 patients with PD were enrolled, of which 612 had dementia, exhibiting significant disability in all three tasks. After adjustments for age, sex, and PD severity, pen holding and knotting were significantly associated with PD dementia. The presence of any disability in either task was not only sensitive to the presence of dementia but also associated with cognitive disability in moderate and advanced PD patients without dementia. In conclusion, hand fine motor skill disability was associated with cognitive disability in patients with moderate-to-advanced PD. These simple hand fine motor skills may thus be applicable in screening tests for the early identification of cognitive dysfunction in patients with moderate-to-advanced PD.
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spelling pubmed-73496652020-07-15 Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease Tan, Shennie Hong, Chien Tai Chen, Jia-Hung Chan, Lung Chi, Wen-Chou Yen, Chia-Feng Liao, Hua-Fang Liou, Tsan-Hon Wu, Dean Brain Sci Article In older individuals, hand fine motor skill disability is associated with cognitive levels. Similarly, patients with moderate-to-advanced Parkinson’s disease (PD) often have cognitive dysfunction. Here, we investigated the association between hand fine motor skill and cognitive dysfunction in patients with moderate-to-advanced PD. Moderate and advanced PD patients with and without dementia were identified from the Taiwan Data Bank of Persons with Disability. Hand fine motor capacities, namely pen holding, buttoning, and knotting, were assessed with the World Health Organization Disability Assessment Schedule 2.0. Statistical analyses were performed on Statistical Analysis System (SAS) and a p value of <0.05 was considered significant. In total, 3440 patients with PD were enrolled, of which 612 had dementia, exhibiting significant disability in all three tasks. After adjustments for age, sex, and PD severity, pen holding and knotting were significantly associated with PD dementia. The presence of any disability in either task was not only sensitive to the presence of dementia but also associated with cognitive disability in moderate and advanced PD patients without dementia. In conclusion, hand fine motor skill disability was associated with cognitive disability in patients with moderate-to-advanced PD. These simple hand fine motor skills may thus be applicable in screening tests for the early identification of cognitive dysfunction in patients with moderate-to-advanced PD. MDPI 2020-06-02 /pmc/articles/PMC7349665/ /pubmed/32498218 http://dx.doi.org/10.3390/brainsci10060337 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tan, Shennie
Hong, Chien Tai
Chen, Jia-Hung
Chan, Lung
Chi, Wen-Chou
Yen, Chia-Feng
Liao, Hua-Fang
Liou, Tsan-Hon
Wu, Dean
Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title_full Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title_fullStr Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title_full_unstemmed Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title_short Hand Fine Motor Skill Disability Correlates with Cognition in Patients with Moderate-to-Advanced Parkinson’s Disease
title_sort hand fine motor skill disability correlates with cognition in patients with moderate-to-advanced parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349665/
https://www.ncbi.nlm.nih.gov/pubmed/32498218
http://dx.doi.org/10.3390/brainsci10060337
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