Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells

The core spliceosomal Sm proteins were recently proposed as cancer-selective lethal targets in non-small cell lung cancer (NSCLC). In contrast, the loss of the commonly mutated cancer target SF3B1 appeared to be toxic to non-malignant cells as well. In the current study, the transcriptomes of A549 N...

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Detalles Bibliográficos
Autores principales: Blijlevens, Maxime, Komor, Malgorzata A., Sciarrillo, Rocco, Smit, Egbert F., Fijneman, Remond J. A., van Beusechem, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349683/
https://www.ncbi.nlm.nih.gov/pubmed/32545483
http://dx.doi.org/10.3390/ijms21124192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349683/
https://www.ncbi.nlm.nih.gov/pubmed/32545483
http://dx.doi.org/10.3390/ijms21124192

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