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Silencing Core Spliceosome Sm Gene Expression Induces a Cytotoxic Splicing Switch in the Proteasome Subunit Beta 3 mRNA in Non-Small Cell Lung Cancer Cells
The core spliceosomal Sm proteins were recently proposed as cancer-selective lethal targets in non-small cell lung cancer (NSCLC). In contrast, the loss of the commonly mutated cancer target SF3B1 appeared to be toxic to non-malignant cells as well. In the current study, the transcriptomes of A549 N...
Autores principales: | Blijlevens, Maxime, Komor, Malgorzata A., Sciarrillo, Rocco, Smit, Egbert F., Fijneman, Remond J. A., van Beusechem, Victor W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349683/ https://www.ncbi.nlm.nih.gov/pubmed/32545483 http://dx.doi.org/10.3390/ijms21124192 |
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