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Effects of GH/IGF on the Aging Mitochondria

The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significa...

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Autores principales: Poudel, Sher Bahadur, Dixit, Manisha, Neginskaya, Maria, Nagaraj, Karthik, Pavlov, Evgeny, Werner, Haim, Yakar, Shoshana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349719/
https://www.ncbi.nlm.nih.gov/pubmed/32498386
http://dx.doi.org/10.3390/cells9061384
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author Poudel, Sher Bahadur
Dixit, Manisha
Neginskaya, Maria
Nagaraj, Karthik
Pavlov, Evgeny
Werner, Haim
Yakar, Shoshana
author_facet Poudel, Sher Bahadur
Dixit, Manisha
Neginskaya, Maria
Nagaraj, Karthik
Pavlov, Evgeny
Werner, Haim
Yakar, Shoshana
author_sort Poudel, Sher Bahadur
collection PubMed
description The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging.
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spelling pubmed-73497192020-07-15 Effects of GH/IGF on the Aging Mitochondria Poudel, Sher Bahadur Dixit, Manisha Neginskaya, Maria Nagaraj, Karthik Pavlov, Evgeny Werner, Haim Yakar, Shoshana Cells Review The mitochondria are key organelles regulating vital processes in the eukaryote cell. A decline in mitochondrial function is one of the hallmarks of aging. Growth hormone (GH) and the insulin-like growth factor-1 (IGF-1) are somatotropic hormones that regulate cellular homeostasis and play significant roles in cell differentiation, function, and survival. In mammals, these hormones peak during puberty and decline gradually during adulthood and aging. Here, we review the evidence that GH and IGF-1 regulate mitochondrial mass and function and contribute to specific processes of cellular aging. Specifically, we discuss the contribution of GH and IGF-1 to mitochondrial biogenesis, respiration and ATP production, oxidative stress, senescence, and apoptosis. Particular emphasis was placed on how these pathways intersect during aging. MDPI 2020-06-02 /pmc/articles/PMC7349719/ /pubmed/32498386 http://dx.doi.org/10.3390/cells9061384 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Poudel, Sher Bahadur
Dixit, Manisha
Neginskaya, Maria
Nagaraj, Karthik
Pavlov, Evgeny
Werner, Haim
Yakar, Shoshana
Effects of GH/IGF on the Aging Mitochondria
title Effects of GH/IGF on the Aging Mitochondria
title_full Effects of GH/IGF on the Aging Mitochondria
title_fullStr Effects of GH/IGF on the Aging Mitochondria
title_full_unstemmed Effects of GH/IGF on the Aging Mitochondria
title_short Effects of GH/IGF on the Aging Mitochondria
title_sort effects of gh/igf on the aging mitochondria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349719/
https://www.ncbi.nlm.nih.gov/pubmed/32498386
http://dx.doi.org/10.3390/cells9061384
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