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Orphan G Protein Coupled Receptors in Affective Disorders

G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antid...

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Detalles Bibliográficos
Autores principales: Watkins, Lyndsay R., Orlandi, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349732/
https://www.ncbi.nlm.nih.gov/pubmed/32599826
http://dx.doi.org/10.3390/genes11060694
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author Watkins, Lyndsay R.
Orlandi, Cesare
author_facet Watkins, Lyndsay R.
Orlandi, Cesare
author_sort Watkins, Lyndsay R.
collection PubMed
description G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and are therefore known as orphan GPCRs (oGPCRs). Nonetheless, growing evidence from animal studies, together with genome wide association studies (GWAS) and post-mortem transcriptomic analysis in patients, pointed at many oGPCRs as potential pharmacological targets. Among these discoveries, we summarize in this review how emotional behaviors are modulated by the following oGPCRs: ADGRB2 (BAI2), ADGRG1 (GPR56), GPR3, GPR26, GPR37, GPR50, GPR52, GPR61, GPR62, GPR88, GPR135, GPR158, and GPRC5B.
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spelling pubmed-73497322020-07-15 Orphan G Protein Coupled Receptors in Affective Disorders Watkins, Lyndsay R. Orlandi, Cesare Genes (Basel) Review G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and are therefore known as orphan GPCRs (oGPCRs). Nonetheless, growing evidence from animal studies, together with genome wide association studies (GWAS) and post-mortem transcriptomic analysis in patients, pointed at many oGPCRs as potential pharmacological targets. Among these discoveries, we summarize in this review how emotional behaviors are modulated by the following oGPCRs: ADGRB2 (BAI2), ADGRG1 (GPR56), GPR3, GPR26, GPR37, GPR50, GPR52, GPR61, GPR62, GPR88, GPR135, GPR158, and GPRC5B. MDPI 2020-06-24 /pmc/articles/PMC7349732/ /pubmed/32599826 http://dx.doi.org/10.3390/genes11060694 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Watkins, Lyndsay R.
Orlandi, Cesare
Orphan G Protein Coupled Receptors in Affective Disorders
title Orphan G Protein Coupled Receptors in Affective Disorders
title_full Orphan G Protein Coupled Receptors in Affective Disorders
title_fullStr Orphan G Protein Coupled Receptors in Affective Disorders
title_full_unstemmed Orphan G Protein Coupled Receptors in Affective Disorders
title_short Orphan G Protein Coupled Receptors in Affective Disorders
title_sort orphan g protein coupled receptors in affective disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349732/
https://www.ncbi.nlm.nih.gov/pubmed/32599826
http://dx.doi.org/10.3390/genes11060694
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