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Orphan G Protein Coupled Receptors in Affective Disorders
G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antid...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349732/ https://www.ncbi.nlm.nih.gov/pubmed/32599826 http://dx.doi.org/10.3390/genes11060694 |
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author | Watkins, Lyndsay R. Orlandi, Cesare |
author_facet | Watkins, Lyndsay R. Orlandi, Cesare |
author_sort | Watkins, Lyndsay R. |
collection | PubMed |
description | G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and are therefore known as orphan GPCRs (oGPCRs). Nonetheless, growing evidence from animal studies, together with genome wide association studies (GWAS) and post-mortem transcriptomic analysis in patients, pointed at many oGPCRs as potential pharmacological targets. Among these discoveries, we summarize in this review how emotional behaviors are modulated by the following oGPCRs: ADGRB2 (BAI2), ADGRG1 (GPR56), GPR3, GPR26, GPR37, GPR50, GPR52, GPR61, GPR62, GPR88, GPR135, GPR158, and GPRC5B. |
format | Online Article Text |
id | pubmed-7349732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73497322020-07-15 Orphan G Protein Coupled Receptors in Affective Disorders Watkins, Lyndsay R. Orlandi, Cesare Genes (Basel) Review G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and are therefore known as orphan GPCRs (oGPCRs). Nonetheless, growing evidence from animal studies, together with genome wide association studies (GWAS) and post-mortem transcriptomic analysis in patients, pointed at many oGPCRs as potential pharmacological targets. Among these discoveries, we summarize in this review how emotional behaviors are modulated by the following oGPCRs: ADGRB2 (BAI2), ADGRG1 (GPR56), GPR3, GPR26, GPR37, GPR50, GPR52, GPR61, GPR62, GPR88, GPR135, GPR158, and GPRC5B. MDPI 2020-06-24 /pmc/articles/PMC7349732/ /pubmed/32599826 http://dx.doi.org/10.3390/genes11060694 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Watkins, Lyndsay R. Orlandi, Cesare Orphan G Protein Coupled Receptors in Affective Disorders |
title | Orphan G Protein Coupled Receptors in Affective Disorders |
title_full | Orphan G Protein Coupled Receptors in Affective Disorders |
title_fullStr | Orphan G Protein Coupled Receptors in Affective Disorders |
title_full_unstemmed | Orphan G Protein Coupled Receptors in Affective Disorders |
title_short | Orphan G Protein Coupled Receptors in Affective Disorders |
title_sort | orphan g protein coupled receptors in affective disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349732/ https://www.ncbi.nlm.nih.gov/pubmed/32599826 http://dx.doi.org/10.3390/genes11060694 |
work_keys_str_mv | AT watkinslyndsayr orphangproteincoupledreceptorsinaffectivedisorders AT orlandicesare orphangproteincoupledreceptorsinaffectivedisorders |