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The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights

This retrospective observational study aimed to provide insights on the use of clinical nutrition (CN) (enteral and parenteral feeding) and outcomes in an Italian real-world setting. The data source comes from administrative databases of 10 Italian Local Health Units. Patients diagnosed with maligna...

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Autores principales: Pedrazzoli, Paolo, Caccialanza, Riccardo, Cotogni, Paolo, Degli Esposti, Luca, Perrone, Valentina, Sangiorgi, Diego, Di Costanzo, Francesco, Gavazzi, Cecilia, Santoro, Armando, Pinto, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349883/
https://www.ncbi.nlm.nih.gov/pubmed/32384639
http://dx.doi.org/10.3390/healthcare8020125
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author Pedrazzoli, Paolo
Caccialanza, Riccardo
Cotogni, Paolo
Degli Esposti, Luca
Perrone, Valentina
Sangiorgi, Diego
Di Costanzo, Francesco
Gavazzi, Cecilia
Santoro, Armando
Pinto, Carmine
author_facet Pedrazzoli, Paolo
Caccialanza, Riccardo
Cotogni, Paolo
Degli Esposti, Luca
Perrone, Valentina
Sangiorgi, Diego
Di Costanzo, Francesco
Gavazzi, Cecilia
Santoro, Armando
Pinto, Carmine
author_sort Pedrazzoli, Paolo
collection PubMed
description This retrospective observational study aimed to provide insights on the use of clinical nutrition (CN) (enteral and parenteral feeding) and outcomes in an Italian real-world setting. The data source comes from administrative databases of 10 Italian Local Health Units. Patients diagnosed with malignant neoplasms from 1 January 2010 to 31 December 2015 were included. Metastasis presence was ascertained by discharge diagnosis in the hospitalization database. CN was identified by specific codes from pharmaceutical and hospitalization databases. Two cohorts were created—one for metastatic patients (N = 53,042), and one for non-metastatic patients (N = 4379) receiving CN. Two survival analyses were set for the cohort of metastatic patients—one included patients receiving CN and the second included malnourished patients. Our findings show that (1) administration of CN is associated with positive survival outcomes in metastatic patients with gastrointestinal, respiratory, and genitourinary cancer; (2) CN in malnourished metastatic patients with gastrointestinal and genitourinary cancer was associated with significant improvement in survival; (3) early administration of CN was associated with improvement in survival in non-metastatic patients with gastrointestinal cancer (HR 95%CI: 0.5 (0.4–0.6), p-value < 0.05). This study highlights the need to improve the assessment of nutritional status in oncologic patients and suggests a potential survival benefit of CN treatment in metastatic disease.
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spelling pubmed-73498832020-07-15 The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights Pedrazzoli, Paolo Caccialanza, Riccardo Cotogni, Paolo Degli Esposti, Luca Perrone, Valentina Sangiorgi, Diego Di Costanzo, Francesco Gavazzi, Cecilia Santoro, Armando Pinto, Carmine Healthcare (Basel) Article This retrospective observational study aimed to provide insights on the use of clinical nutrition (CN) (enteral and parenteral feeding) and outcomes in an Italian real-world setting. The data source comes from administrative databases of 10 Italian Local Health Units. Patients diagnosed with malignant neoplasms from 1 January 2010 to 31 December 2015 were included. Metastasis presence was ascertained by discharge diagnosis in the hospitalization database. CN was identified by specific codes from pharmaceutical and hospitalization databases. Two cohorts were created—one for metastatic patients (N = 53,042), and one for non-metastatic patients (N = 4379) receiving CN. Two survival analyses were set for the cohort of metastatic patients—one included patients receiving CN and the second included malnourished patients. Our findings show that (1) administration of CN is associated with positive survival outcomes in metastatic patients with gastrointestinal, respiratory, and genitourinary cancer; (2) CN in malnourished metastatic patients with gastrointestinal and genitourinary cancer was associated with significant improvement in survival; (3) early administration of CN was associated with improvement in survival in non-metastatic patients with gastrointestinal cancer (HR 95%CI: 0.5 (0.4–0.6), p-value < 0.05). This study highlights the need to improve the assessment of nutritional status in oncologic patients and suggests a potential survival benefit of CN treatment in metastatic disease. MDPI 2020-05-06 /pmc/articles/PMC7349883/ /pubmed/32384639 http://dx.doi.org/10.3390/healthcare8020125 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pedrazzoli, Paolo
Caccialanza, Riccardo
Cotogni, Paolo
Degli Esposti, Luca
Perrone, Valentina
Sangiorgi, Diego
Di Costanzo, Francesco
Gavazzi, Cecilia
Santoro, Armando
Pinto, Carmine
The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title_full The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title_fullStr The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title_full_unstemmed The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title_short The Advantages of Clinical Nutrition Use in Oncologic Patients in Italy: Real World Insights
title_sort advantages of clinical nutrition use in oncologic patients in italy: real world insights
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349883/
https://www.ncbi.nlm.nih.gov/pubmed/32384639
http://dx.doi.org/10.3390/healthcare8020125
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