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Urobiome in Gender—Related Diversities of Bladder Cancer
Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349933/ https://www.ncbi.nlm.nih.gov/pubmed/32599810 http://dx.doi.org/10.3390/ijms21124488 |
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author | Bilski, Konrad Dobruch, Jakub Kozikowski, Mieszko Skrzypczyk, Michał A. Oszczudłowski, Maciej Ostrowski, Jerzy |
author_facet | Bilski, Konrad Dobruch, Jakub Kozikowski, Mieszko Skrzypczyk, Michał A. Oszczudłowski, Maciej Ostrowski, Jerzy |
author_sort | Bilski, Konrad |
collection | PubMed |
description | Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC. |
format | Online Article Text |
id | pubmed-7349933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73499332020-07-15 Urobiome in Gender—Related Diversities of Bladder Cancer Bilski, Konrad Dobruch, Jakub Kozikowski, Mieszko Skrzypczyk, Michał A. Oszczudłowski, Maciej Ostrowski, Jerzy Int J Mol Sci Review Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC. MDPI 2020-06-24 /pmc/articles/PMC7349933/ /pubmed/32599810 http://dx.doi.org/10.3390/ijms21124488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bilski, Konrad Dobruch, Jakub Kozikowski, Mieszko Skrzypczyk, Michał A. Oszczudłowski, Maciej Ostrowski, Jerzy Urobiome in Gender—Related Diversities of Bladder Cancer |
title | Urobiome in Gender—Related Diversities of Bladder Cancer |
title_full | Urobiome in Gender—Related Diversities of Bladder Cancer |
title_fullStr | Urobiome in Gender—Related Diversities of Bladder Cancer |
title_full_unstemmed | Urobiome in Gender—Related Diversities of Bladder Cancer |
title_short | Urobiome in Gender—Related Diversities of Bladder Cancer |
title_sort | urobiome in gender—related diversities of bladder cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349933/ https://www.ncbi.nlm.nih.gov/pubmed/32599810 http://dx.doi.org/10.3390/ijms21124488 |
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