Cargando…

Urobiome in Gender—Related Diversities of Bladder Cancer

Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: Bilski, Konrad, Dobruch, Jakub, Kozikowski, Mieszko, Skrzypczyk, Michał A., Oszczudłowski, Maciej, Ostrowski, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349933/
https://www.ncbi.nlm.nih.gov/pubmed/32599810
http://dx.doi.org/10.3390/ijms21124488
_version_ 1783557169585586176
author Bilski, Konrad
Dobruch, Jakub
Kozikowski, Mieszko
Skrzypczyk, Michał A.
Oszczudłowski, Maciej
Ostrowski, Jerzy
author_facet Bilski, Konrad
Dobruch, Jakub
Kozikowski, Mieszko
Skrzypczyk, Michał A.
Oszczudłowski, Maciej
Ostrowski, Jerzy
author_sort Bilski, Konrad
collection PubMed
description Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC.
format Online
Article
Text
id pubmed-7349933
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-73499332020-07-15 Urobiome in Gender—Related Diversities of Bladder Cancer Bilski, Konrad Dobruch, Jakub Kozikowski, Mieszko Skrzypczyk, Michał A. Oszczudłowski, Maciej Ostrowski, Jerzy Int J Mol Sci Review Bladder cancer (BC) remains the most common malignancy of urinary tract. Sex-related differences in BC epidemiology, diagnosis, therapy, and outcomes have been reported. Throughout the recent years, extensive research has been devoted to genetic and molecular alterations in BC. Apart from the molecular background, another related concept which has been speculated to contribute to gender diversities in BC is the role of urinary pathogens in bladder carcinogenesis. Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that perturbation in the microbiome is associated with various human diseases. The aim of this review is to comprehensively analyze the current literature according to sex-related differences in the microbiome composition in BC. MDPI 2020-06-24 /pmc/articles/PMC7349933/ /pubmed/32599810 http://dx.doi.org/10.3390/ijms21124488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bilski, Konrad
Dobruch, Jakub
Kozikowski, Mieszko
Skrzypczyk, Michał A.
Oszczudłowski, Maciej
Ostrowski, Jerzy
Urobiome in Gender—Related Diversities of Bladder Cancer
title Urobiome in Gender—Related Diversities of Bladder Cancer
title_full Urobiome in Gender—Related Diversities of Bladder Cancer
title_fullStr Urobiome in Gender—Related Diversities of Bladder Cancer
title_full_unstemmed Urobiome in Gender—Related Diversities of Bladder Cancer
title_short Urobiome in Gender—Related Diversities of Bladder Cancer
title_sort urobiome in gender—related diversities of bladder cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349933/
https://www.ncbi.nlm.nih.gov/pubmed/32599810
http://dx.doi.org/10.3390/ijms21124488
work_keys_str_mv AT bilskikonrad urobiomeingenderrelateddiversitiesofbladdercancer
AT dobruchjakub urobiomeingenderrelateddiversitiesofbladdercancer
AT kozikowskimieszko urobiomeingenderrelateddiversitiesofbladdercancer
AT skrzypczykmichała urobiomeingenderrelateddiversitiesofbladdercancer
AT oszczudłowskimaciej urobiomeingenderrelateddiversitiesofbladdercancer
AT ostrowskijerzy urobiomeingenderrelateddiversitiesofbladdercancer