N-Terminal Fatty Acids of NEF(MUT) Are Required for the CD8(+) T-Cell Immunogenicity of In Vivo Engineered Extracellular Vesicles

We recently described a cytotoxic CD8(+) T lymphocyte (CTL) vaccine platform based on the intramuscular (i.m.) injection of DNA eukaryotic vectors expressing antigens of interest fused at the C-terminus of HIV-1 Nef(mut), i.e., a functionally defective mutant that is incorporated at quite high level...

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Detalles Bibliográficos
Autores principales: Chiozzini, Chiara, Manfredi, Francesco, Arenaccio, Claudia, Ferrantelli, Flavia, Leone, Patrizia, Federico, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350016/
https://www.ncbi.nlm.nih.gov/pubmed/32456079
http://dx.doi.org/10.3390/vaccines8020243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350016/
https://www.ncbi.nlm.nih.gov/pubmed/32456079
http://dx.doi.org/10.3390/vaccines8020243

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