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Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several pr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350224/ https://www.ncbi.nlm.nih.gov/pubmed/32630505 http://dx.doi.org/10.3390/ijms21124521 |
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author | Elmahallawy, Ehab Kotb Mohamed, Yasser Abdo, Walied Yanai, Tokuma |
author_facet | Elmahallawy, Ehab Kotb Mohamed, Yasser Abdo, Walied Yanai, Tokuma |
author_sort | Elmahallawy, Ehab Kotb |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC. |
format | Online Article Text |
id | pubmed-7350224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73502242020-07-22 Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment Elmahallawy, Ehab Kotb Mohamed, Yasser Abdo, Walied Yanai, Tokuma Int J Mol Sci Review Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC. MDPI 2020-06-25 /pmc/articles/PMC7350224/ /pubmed/32630505 http://dx.doi.org/10.3390/ijms21124521 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Elmahallawy, Ehab Kotb Mohamed, Yasser Abdo, Walied Yanai, Tokuma Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title_full | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title_fullStr | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title_full_unstemmed | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title_short | Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment |
title_sort | melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350224/ https://www.ncbi.nlm.nih.gov/pubmed/32630505 http://dx.doi.org/10.3390/ijms21124521 |
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