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Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment

Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several pr...

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Detalles Bibliográficos
Autores principales: Elmahallawy, Ehab Kotb, Mohamed, Yasser, Abdo, Walied, Yanai, Tokuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350224/
https://www.ncbi.nlm.nih.gov/pubmed/32630505
http://dx.doi.org/10.3390/ijms21124521
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author Elmahallawy, Ehab Kotb
Mohamed, Yasser
Abdo, Walied
Yanai, Tokuma
author_facet Elmahallawy, Ehab Kotb
Mohamed, Yasser
Abdo, Walied
Yanai, Tokuma
author_sort Elmahallawy, Ehab Kotb
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC.
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spelling pubmed-73502242020-07-22 Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment Elmahallawy, Ehab Kotb Mohamed, Yasser Abdo, Walied Yanai, Tokuma Int J Mol Sci Review Hepatocellular carcinoma (HCC) is the most common hepatobiliary malignancy with limited therapeutic options. On the other hand, melatonin is an indoleamine that modulates a variety of potential therapeutic effects. In addition to its important role in the regulation of sleep–wake rhythms, several previous studies linked the biologic effects of melatonin to various substantial endocrine, neural, immune and antioxidant functions, among others. Furthermore, the effects of melatonin could be influenced through receptor dependent and receptor independent manner. Among the other numerous physiological and therapeutic effects of melatonin, controlling the survival and differentiation of mesenchymal stem cells (MSCs) has been recently discussed. Given its controversial interaction, several previous reports revealed the therapeutic potential of MSCs in controlling the hepatocellular carcinoma (HCC). Taken together, the intention of the present review is to highlight the effects of melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. We hope to provide solid piece of information that may be helpful in designing novel drug targets to control HCC. MDPI 2020-06-25 /pmc/articles/PMC7350224/ /pubmed/32630505 http://dx.doi.org/10.3390/ijms21124521 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Elmahallawy, Ehab Kotb
Mohamed, Yasser
Abdo, Walied
Yanai, Tokuma
Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title_full Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title_fullStr Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title_full_unstemmed Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title_short Melatonin and Mesenchymal Stem Cells as a Key for Functional Integrity for Liver Cancer Treatment
title_sort melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350224/
https://www.ncbi.nlm.nih.gov/pubmed/32630505
http://dx.doi.org/10.3390/ijms21124521
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