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The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control

African swine fever (ASF) is, once more, spreading throughout the world. After its recent reintroduction in Georgia, it quickly reached many neighboring countries in Eastern Europe. It was also detected in Asia, infecting China, the world’s biggest pig producer, and spreading to many of the surround...

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Autores principales: Coelho, João, Leitão, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350233/
https://www.ncbi.nlm.nih.gov/pubmed/32560397
http://dx.doi.org/10.3390/vaccines8020312
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author Coelho, João
Leitão, Alexandre
author_facet Coelho, João
Leitão, Alexandre
author_sort Coelho, João
collection PubMed
description African swine fever (ASF) is, once more, spreading throughout the world. After its recent reintroduction in Georgia, it quickly reached many neighboring countries in Eastern Europe. It was also detected in Asia, infecting China, the world’s biggest pig producer, and spreading to many of the surrounding countries. Without any vaccine or effective treatment currently available, new strategies for the control of the disease are mandatory. Its etiological agent, the African swine fever virus (ASFV), has been shown to code for a type II DNA topoisomerase. These are enzymes capable of modulating the topology of DNA molecules, known to be essential in unicellular and multicellular organisms, and constitute targets in antibacterial and anti-cancer treatments. In this review, we summarize most of what is known about this viral enzyme, pP1192R, and discuss about its possible role(s) during infection. Given the essential role of type II topoisomerases in cells, the data so far suggest that pP1192R is likely to be equally essential for the virus and thus a promising target for the elaboration of a replication-defective virus, which could provide the basis for an effective vaccine. Furthermore, the use of inhibitors could be considered to control the spread of the infection during outbreaks and therefore limit the spreading of the disease.
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spelling pubmed-73502332020-07-22 The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control Coelho, João Leitão, Alexandre Vaccines (Basel) Review African swine fever (ASF) is, once more, spreading throughout the world. After its recent reintroduction in Georgia, it quickly reached many neighboring countries in Eastern Europe. It was also detected in Asia, infecting China, the world’s biggest pig producer, and spreading to many of the surrounding countries. Without any vaccine or effective treatment currently available, new strategies for the control of the disease are mandatory. Its etiological agent, the African swine fever virus (ASFV), has been shown to code for a type II DNA topoisomerase. These are enzymes capable of modulating the topology of DNA molecules, known to be essential in unicellular and multicellular organisms, and constitute targets in antibacterial and anti-cancer treatments. In this review, we summarize most of what is known about this viral enzyme, pP1192R, and discuss about its possible role(s) during infection. Given the essential role of type II topoisomerases in cells, the data so far suggest that pP1192R is likely to be equally essential for the virus and thus a promising target for the elaboration of a replication-defective virus, which could provide the basis for an effective vaccine. Furthermore, the use of inhibitors could be considered to control the spread of the infection during outbreaks and therefore limit the spreading of the disease. MDPI 2020-06-17 /pmc/articles/PMC7350233/ /pubmed/32560397 http://dx.doi.org/10.3390/vaccines8020312 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coelho, João
Leitão, Alexandre
The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title_full The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title_fullStr The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title_full_unstemmed The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title_short The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control
title_sort african swine fever virus (asfv) topoisomerase ii as a target for viral prevention and control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350233/
https://www.ncbi.nlm.nih.gov/pubmed/32560397
http://dx.doi.org/10.3390/vaccines8020312
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