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Gut Microbiome in Psoriasis: An Updated Review

(1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The...

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Autores principales: Sikora, Mariusz, Stec, Albert, Chrabaszcz, Magdalena, Knot, Aleksandra, Waskiel-Burnat, Anna, Rakowska, Adriana, Olszewska, Malgorzata, Rudnicka, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350295/
https://www.ncbi.nlm.nih.gov/pubmed/32545459
http://dx.doi.org/10.3390/pathogens9060463
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author Sikora, Mariusz
Stec, Albert
Chrabaszcz, Magdalena
Knot, Aleksandra
Waskiel-Burnat, Anna
Rakowska, Adriana
Olszewska, Malgorzata
Rudnicka, Lidia
author_facet Sikora, Mariusz
Stec, Albert
Chrabaszcz, Magdalena
Knot, Aleksandra
Waskiel-Burnat, Anna
Rakowska, Adriana
Olszewska, Malgorzata
Rudnicka, Lidia
author_sort Sikora, Mariusz
collection PubMed
description (1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy.
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spelling pubmed-73502952020-07-15 Gut Microbiome in Psoriasis: An Updated Review Sikora, Mariusz Stec, Albert Chrabaszcz, Magdalena Knot, Aleksandra Waskiel-Burnat, Anna Rakowska, Adriana Olszewska, Malgorzata Rudnicka, Lidia Pathogens Review (1) Background: A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis. The gut–skin axis is the novel concept of the interaction between skin diseases and microbiome through inflammatory mediators, metabolites and the intestinal barrier. The objective of this study was to synthesize current data on the gut microbial composition in psoriasis. (2) Methods: We conducted a systematic review of studies investigating intestinal microbiome in psoriasis, using the PRISMA checklist. We searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2000–2020). (3) Results: All of the 10 retrieved studies reported alterations in the gut microbiome in patients with psoriasis. Eight studies assessed alpha- and beta-diversity. Four of them reported a lack of change in alpha-diversity, but all confirmed significant changes in beta-diversity. At the phylum-level, at least two or more studies reported a lower relative abundance of Bacteroidetes, and higher Firmicutes in psoriasis patients versus healthy controls. (4) Conclusions: There is a significant association between alterations in gut microbial composition and psoriasis; however, there is high heterogeneity between studies. More unified methodological standards in large-scale studies are needed to understand microbiota’s contribution to psoriasis pathogenesis and its modulation as a potential therapeutic strategy. MDPI 2020-06-12 /pmc/articles/PMC7350295/ /pubmed/32545459 http://dx.doi.org/10.3390/pathogens9060463 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sikora, Mariusz
Stec, Albert
Chrabaszcz, Magdalena
Knot, Aleksandra
Waskiel-Burnat, Anna
Rakowska, Adriana
Olszewska, Malgorzata
Rudnicka, Lidia
Gut Microbiome in Psoriasis: An Updated Review
title Gut Microbiome in Psoriasis: An Updated Review
title_full Gut Microbiome in Psoriasis: An Updated Review
title_fullStr Gut Microbiome in Psoriasis: An Updated Review
title_full_unstemmed Gut Microbiome in Psoriasis: An Updated Review
title_short Gut Microbiome in Psoriasis: An Updated Review
title_sort gut microbiome in psoriasis: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350295/
https://www.ncbi.nlm.nih.gov/pubmed/32545459
http://dx.doi.org/10.3390/pathogens9060463
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